4-[(E)-2-(4-fluorophenyl)-1-phenylethenyl]phenol

Names

[ CAS No. ]:
299-09-2

[ Name ]:
4-[(E)-2-(4-fluorophenyl)-1-phenylethenyl]phenol

Chemical & Physical Properties

[ Density]:
1.201g/cm3

[ Boiling Point ]:
397.2ºC at 760mmHg

[ Molecular Formula ]:
C20H15FO

[ Molecular Weight ]:
290.33100

[ Flash Point ]:
248.2ºC

[ Exact Mass ]:
290.11100

[ PSA ]:
20.23000

[ LogP ]:
5.12020

[ Vapour Pressure ]:
7.07E-07mmHg at 25°C

[ Index of Refraction ]:
1.653

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL4585200
CHEMICAL NAME :
Phenol, p-(p-fluoro-alpha-phenylstyryl)-
CAS REGISTRY NUMBER :
299-09-2
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H15-F-O
MOLECULAR WEIGHT :
290.35
WISWESSER LINE NOTATION :
QR DYR&U1R DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 151,475,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3 mg/kg
SEX/DURATION :
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 151,475,1964

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-benzyloxybenzophenone
  • 4-Fluorobenzyl chloride

DownStream

Related Compounds

  • 4-[(E)-2-(2-fluorophenyl)-1-phenylethenyl]phenol
  • 4-[(E)-2-(3-fluorophenyl)-1-phenylethenyl]phenol
  • 1-[2-(4-fluorophenyl)-1-phenylethenyl]pyrrolidine
  • 4-[(Z)-2-bromo-2-(4-fluorophenyl)-1-phenylethenyl]phenol
  • GDC-0810
  • Trans-4-hydroxystilbene
  • Lenalidomide-5'-CO-C2-acid
  • 2-aminoethyl N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]carbamate
  • Lenalidomide-5'-CO-C4-alkyne
  • Pomalidomide-5'-C5-alkyne
  • tert-butyl 3-[[4-[(2S)-2-hydroxypropyl]piperazin-1-yl]methyl]-8-azabicyclo[3.2.1]octane-8-carboxylate
  • 3-[6-(8-Hydroxyoct-1-ynyl)-1-oxo-isoindolin-2-yl]piperidine-2,6-dione
  • 1-[3-(Bromomethyl)-5-tert-butyl-4-methoxy-phenyl]hexahydropyrimidine-2,4-dione
  • Lenalidomide-5'-CO-PEG1-propargyl
  • Phthalimidinoglutarimide-5'-propargyl-O-C2-acid
  • 2-(2,6-Dioxo-3-piperidyl)-5-(piperazine-1-carbonyl)isoindoline-1,3-dione
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