4-[(E)-2-(4-fluorophenyl)-1-phenylethenyl]phenol

Names

[ CAS No. ]:
299-09-2

[ Name ]:
4-[(E)-2-(4-fluorophenyl)-1-phenylethenyl]phenol

Chemical & Physical Properties

[ Density]:
1.201g/cm3

[ Boiling Point ]:
397.2ºC at 760mmHg

[ Molecular Formula ]:
C20H15FO

[ Molecular Weight ]:
290.33100

[ Flash Point ]:
248.2ºC

[ Exact Mass ]:
290.11100

[ PSA ]:
20.23000

[ LogP ]:
5.12020

[ Vapour Pressure ]:
7.07E-07mmHg at 25°C

[ Index of Refraction ]:
1.653

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SL4585200
CHEMICAL NAME :
Phenol, p-(p-fluoro-alpha-phenylstyryl)-
CAS REGISTRY NUMBER :
299-09-2
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H15-F-O
MOLECULAR WEIGHT :
290.35
WISWESSER LINE NOTATION :
QR DYR&U1R DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
male 10 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 151,475,1964
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3 mg/kg
SEX/DURATION :
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 151,475,1964

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-benzyloxybenzophenone
  • 4-Fluorobenzyl chloride

DownStream

Related Compounds

  • 4-[(E)-2-(2-fluorophenyl)-1-phenylethenyl]phenol
  • 4-[(E)-2-(3-fluorophenyl)-1-phenylethenyl]phenol
  • 1-[2-(4-fluorophenyl)-1-phenylethenyl]pyrrolidine
  • 4-[(Z)-2-bromo-2-(4-fluorophenyl)-1-phenylethenyl]phenol
  • GDC-0810
  • Trans-4-hydroxystilbene
  • tert-Butyl (2-hydroxy-1-(pyridin-3-yl)ethyl)carbamate
  • 2-[(4-Methoxyphenyl)sulfanyl]cyclopentan-1-one
  • [(2R,4S)-2-ethoxy-4-methoxy-6-methyl-3,4-dihydro-2H-pyran-5-yl]methanol
  • 2-(4-Fluoro-phenylamino)-thiazole-4-carboxylic acid
  • methyl 4-(1-phenyl-5-((pyrimidin-2-ylthio)methyl)-1H-1,2,3-triazole-4-carboxamido)benzoate
  • ((1S,2S)-2-Phenylcyclopropyl)methanamine
  • 1-[1-(Phenylmethoxy)-2-naphthalenyl]ethanone
  • 1-[1-[(3-Methyl-5-isoxazolyl)methoxy]-2-naphthalenyl]ethanone
  • 2-[(5-tert-butyl-2-methylphenyl)sulfanyl]-N-(1-cyano-1,2-dimethylpropyl)acetamide
  • N-(2,3-dihydro-1H-inden-1-yl)methanesulfonamide
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