Treosulfan
Suppliers
Names
[ CAS No. ]:
299-75-2
[ Name ]:
Treosulfan
[Synonym ]:
Tresulfan
L-threitol 1,4-bismethane sulfonate
Dihydroxymyleran
L-Dihydroxy-Busulfan
1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate
2,3-dihydroxybutane-1,4-diyl dimethanesulfonate
Dihydroxybusulfan
Treosulfan
Treosulphan
THREOSULFAN
CB-2562
2,3-Dihydroxy-1,4-butanediyl dimethanesulfonate
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
607.0±55.0 °C at 760 mmHg
[ Molecular Formula ]:
C6H14O8S2
[ Molecular Weight ]:
278.301
[ Flash Point ]:
320.9±31.5 °C
[ Exact Mass ]:
278.013000
[ PSA ]:
143.96000
[ LogP ]:
-1.64
[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C
[ Index of Refraction ]:
1.518
[ Storage condition ]:
2-8℃
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XO8500000
- CHEMICAL NAME :
- L-Threitol, 1,4-bismethanesulfonate
- CAS REGISTRY NUMBER :
- 299-75-2
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C6-H14-O8-S2
- MOLECULAR WEIGHT :
- 278.32
- WISWESSER LINE NOTATION :
- WS1&O1YQYQ1OSW1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 222 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes Blood - leukopenia Blood - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 222 mg/kg
- TOXIC EFFECTS :
- Blood - leukopenia Blood - agranulocytosis Blood - other changes
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TYPE OF TEST :
- Sister chromatid exchange
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TYPE OF TEST :
- Mutation in mammalian somatic cells
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 100 umol/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 21,95,1993 *** REVIEWS *** IARC Cancer Review:Human Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 26,341,1981 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 26,341,1981 IARC Cancer Review:Group 1 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,363,1987
Safety Information
[ RIDADR ]:
UN 2811
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)