2,3-Dibromo-N-methylmaleimide

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Names

[ Name ]:
2,3-Dibromo-N-methylmaleimide

[Synonym ]:
3,4-dibromo-N-methylmaleimide
3,4-dibromo-1-methyl-2,5-dihydro-1H-2,5-pyrroledione
N-Methyl-dibromomaleinimide
MALEIMIDE,DIBROMO-N-METHYL
1-methyl-3,4-dibromomaleimide
Maleimide,2,3-dibromo-N-methyl
2,3-Dibromo-N-methylmaleimide
1-methyl-3,4-dibromo-2,5-dihydro-1H-2,5-pyrroledione
3,4-dibromo-1-methyl-2,5-dihydropyrrole-2,5-dione
N-Methyl-2,3-dibromomaleimide
MFCD00102284

Chemical & Physical Properties

[ Density]:
2.427 g/cm3

[ Boiling Point ]:
246.1ºC at 760 mmHg

[ Melting Point ]:
120-124 °C(lit.)

[ Molecular Formula ]:
C₅H₃Br₂NO₂

[ Molecular Weight ]:
268.89100

[ Flash Point ]:
102.6ºC

[ Exact Mass ]:
266.85300

[ PSA ]:
37.38000

[ LogP ]:
0.92430

[ Index of Refraction ]:
1.686

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ON5125000

CHEMICAL NAME :: Maleimide, dibromo-N-methyl-

CAS REGISTRY NUMBER :: 3005-27-4

BEILSTEIN REFERENCE NO. :: 0129149

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H3-Br2-N-O2

MOLECULAR WEIGHT :: 268.91

WISWESSER LINE NOTATION :: T5VNVJ B1 DE EE

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 62 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,15,1976 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 12500 ug/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,15,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 50 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - abortion

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 37,15,1976

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
ON5125000

[ HS Code ]:
2925190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

1,5-dibromo-3-methyl-3-azabicyclo[3.2.0]hept-6-ene-2,4-dione
Cyclopentadiene
T56 BVNVJ C1
Bisindolylmaleimide IV
n-methylbis(indol-3-yl)maleimide
2,4,5,7,8-pentamethyloxepino[4,5-c]pyrrole-1,3-dione
1-methyl-3,4-bis(1H-pyrrolo[3,2-c]pyridin-1-yl)pyrrole-2,5-dione
1-Boc-1H-pyrrolo[3,2-c]pyridine
3-bromo-4-(1H-indol-3-yl)pyrrole-2,5-dione

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

2,3-dibromo-N-(phenylcarbamoyl)propanamide
2,3-dibromo-N-(4-ethoxyphenyl)-3-phenyl-propanamide
2,3-dibromo-N-(diphenylcarbamoyl)propanamide
2,3-dibromo-N-[(3,5-dichlorophenyl)carbamoyl]propanamide
2,3-dibromo-N-tert-butylpropanamide
2,3-dibromo-N-[(2-hydroxyphenyl)carbamoyl]propanamide