TCS 359

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Names

[ CAS No. ]:
301305-73-7

[ Name ]:
TCS 359

[Synonym ]:
Benzo[b]thiophene-3-carboxamide, 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-
Flt-3 inhibitor
2-[(3,4-Dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
TCS 359

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
454.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H20N2O4S

[ Molecular Weight ]:
360.427

[ Flash Point ]:
228.6±28.7 °C

[ Exact Mass ]:
360.114380

[ PSA ]:
118.89000

[ LogP ]:
4.50

[ Appearance of Characters ]:
white to off-white

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
−20°C

[ Water Solubility ]:
H2O: <2mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.

Bioorg. Med. Chem. Lett. 16 , 3282-3286

A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 mi...


More Articles

Related Compounds

  • TCS-PIM-1-4a
  • TCS 401
  • TCS 5861528
  • TCS-OX2-29
  • TCS 1102
  • TCS 46b
  • 3-(Difluoromethoxy)-6-iodo-2-[(4-methoxybenzyl)oxy]pyridine
  • tert-Butyl (trans-6-amino-2-hydroxy-2,3-dihydro-1H-inden-1-yl)carbamate
  • 1-((1H-Pyrazol-3-yl)methyl)piperazine
  • Cyclopropanepropanoic acid, alpha-(acetylamino)-2-carboxy-, [1S-[1alpha(S*),2beta]]-
  • 1-[1-(1-Phenylethyl)cyclopropyl]ethan-1-one
  • 2-(3,4-Dihydroxybenzoyloxy)ethyl 3,4-dihydroxybenzoate
  • 1-Bromo-2-chloro-4-(ethylsulfonyl)benzene
  • 1-(Chloromethyl)-4-(methanesulfonylmethyl)benzene
  • 1-Bromo-4-(ethylsulfonyl)-2-methylbenzene
  • [4-(Methanesulfonylmethyl)phenyl]methanol
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