CH-223191

Suppliers

Names

[ Name ]:
CH-223191

[Synonym ]:
2-Methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide
UNII-HYE7315Z4C
1H-Pyrazole-5-carboxamide, 1-methyl-N-[2-methyl-4-[(E)-2-(2-methylphenyl)diazenyl]phenyl]-
1-Methyl-N-{2-methyl-4-[(E)-(2-methylphenyl)diazenyl]phenyl}-1H-pyrazole-5-carboxamide
AhR Antagonist
CH-223191

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
469.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₉N₅O

[ Molecular Weight ]:
333.387

[ Flash Point ]:
237.7±28.7 °C

[ Exact Mass ]:
333.158966

[ PSA ]:
75.13000

[ LogP ]:
3.48

[ Appearance of Characters ]:
orange-brown

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
Store at +4°C

[ Water Solubility ]:
DMSO: ≥20mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ Safety Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Articles

The aryl hydrocarbon receptor suppresses osteoblast proliferation and differentiation through the activation of the ERK signaling pathway.

Toxicol. Appl. Pharmacol. 280(3) , 502-10, (2014)

Ahr activation is known to be associated with synovitis and exacerbated rheumatoid arthritis (RA), but its contributions to bone loss have not been completely elucidated. Osteoblast proliferation and ...

In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells.

J. Pharm. Pharmacol. 67(2) , 170-7, (2015)

It has been reported that intestinal urate excretion is increased at chronic kidney disease (CKD) state. In this report, whether uremic toxins are involved in the upregulation of intestinal breast can...

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

Toxicol. Sci. 148 , 261-75, (2015)

Cytochrome P450 (CYP) expression and activity are not homogeneous in the liver lobules. Indeed, CYPs are mainly expressed and induced in centrilobular hepatocytes. The wingless-type MMTV integration s...