D4476

Suppliers

Names

[ Name ]:
D4476

[Synonym ]:
4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide
Benzamide, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-
CK1 Inhibitor
4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
Casein Kinase I Inhibitor
D4476

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
675.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₁₈N₄O₃

[ Molecular Weight ]:
398.414

[ Flash Point ]:
362.0±31.5 °C

[ Exact Mass ]:
398.137878

[ PSA ]:
103.12000

[ LogP ]:
3.84

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.663

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth.

Nat. Commun. 6 , 7215, (2015)

Beclin 1, a protein essential for autophagy, regulates autophagy by interacting with Vps34 and other cofactors to form the Beclin 1 complex. Modifications of Beclin 1 may lead to the induction, inhibi...

Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis.

J. Biol. Chem. 289(23) , 16508-16515, (2014)

Tuberculosis remains the biggest infectious threat to humanity with one-third of the population infected and 1.4 million deaths and 8.7 million new cases annually. Current tuberculosis therapy is leng...

The selectivity of protein kinase inhibitors: a further update.

Biochem. J. 408 , 297-315, (2007)

The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases. On the basis of this information, the ef...