Ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl-, N-oxide, hydrochloride (1:1)

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Names

[ CAS No. ]:
302-70-5

[ Name ]:
Ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl-, N-oxide, hydrochloride (1:1)

[Synonym ]:
Mitomen
Bis-(2-chlor-aethyl)-hydroxy-methyl-ammonium-chlorid
Oxyamine
N,N-Bis-(2-chlor-aethyl)-N-methyl-hydroxylaminium-chlorid
MBAO hydrochloride
Bis-(2-chlor-aethyl)-methyl-aminoxid,Hydrochlorid
Mustron
N-Oxyd-Lost
mechlorethamine oxide hydrochloride
Nitromin
Ossichlorin
Ossiamina
Nitromin hydrochloride
bis-(2-chloro-ethyl)-methyl-amine oxide,hydrochloride
HN2 oxide hydrochloride

Chemical & Physical Properties

[ Melting Point ]:
-60ºC

[ Molecular Formula ]:
C5H12Cl3NO

[ Molecular Weight ]:
208.51400

[ Exact Mass ]:
206.99800

[ PSA ]:
29.43000

[ LogP ]:
2.23130

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
IA2275000
CHEMICAL NAME :
Diethylamine, 2,2'-dichloro-N-methyl-, N-oxide, hydrochloride
CAS REGISTRY NUMBER :
302-70-5
LAST UPDATED :
199510
DATA ITEMS CITED :
19
MOLECULAR FORMULA :
C5-H11-Cl2-N-O.Cl-H
MOLECULAR WEIGHT :
208.53
WISWESSER LINE NOTATION :
G2KO&1&2G &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
79500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
76100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
83 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
125 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Gastrointestinal - other changes Blood - leukopenia Blood - other changes
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Blood - leukopenia Blood - other changes Blood - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Multiple routes
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 mg/kg/93W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Blood - leukemia
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
Body fluid assay
TEST SYSTEM :
Rodent - rat Bacteria - Salmonella typhimurium
DOSE/DURATION :
250 mg/kg
REFERENCE :
URLRA5 Urological Research. (Springer Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1973- Volume(issue)/page/year: 7,119,1979 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,209,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,209,1975 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2921199090

Precursor & DownStream

Precursor

DownStream

  • 2-(2-CHLOROETHYL)METHYLAMINOETHANOLHYDROCHLORIDE

Customs

[ HS Code ]: 2921199090

[ Summary ]:
2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

  • rac-[(2R,5S)-5-[(4-methylpiperazin-1-yl)methyl]oxolan-2-yl]methanamine
  • 4-[(3R)-3-hydroxybutyl]benzene-1,2-diol
  • 1-(1,3-Thiazol-4-yl)ethane-1-thiol
  • Tert-butyl (e)-4-(3-(dimethylamino)-2-(ethoxycarbonyl)acryloyl)piperidine-1-carboxylate
  • (2S,3R)-2-Methyloxetan-3-amine
  • N-(2-(3-oxo-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)ethyl)benzo[c][1,2,5]thiadiazole-5-carboxamide
  • N-(2-(7-fluoro-3-oxo-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)ethyl)-5-(furan-2-yl)isoxazole-3-carboxamide
  • N-(2-(7-fluoro-3-oxo-2,3-dihydrobenzo[f][1,4]oxazepin-4(5H)-yl)ethyl)-2-(4-oxoquinazolin-3(4H)-yl)acetamide
  • 5-chloro-2-methoxy-N-(2-(4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)ethyl)benzenesulfonamide
  • 1-(2-(4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)ethyl)-3-((tetrahydrofuran-2-yl)methyl)urea
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