Prothipendyl

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Names

[ CAS No. ]:
303-69-5

[ Name ]:
Prothipendyl

[Synonym ]:
Prothipendyl
Prothipendylum [INN-Latin]
Prothipendyl [INN:BAN]
LG 206
Largophren
Protipendilo [INN-Spanish]
(3-Benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amin
Tumovan
Timoval
(3-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-dimethyl-amine
Timovan
Dominal
10-<3-Dimethylamino-propyl>-4-aza-phenothiazin

Chemical & Physical Properties

[ Density]:
1.168g/cm3

[ Boiling Point ]:
430.8ºC at 760mmHg

[ Molecular Formula ]:
C16H19N3S

[ Molecular Weight ]:
285.40700

[ Flash Point ]:
214.3ºC

[ Exact Mass ]:
285.13000

[ PSA ]:
44.67000

[ LogP ]:
3.70100

[ Index of Refraction ]:
1.621

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU8576000
CHEMICAL NAME :
10H-Pyrido(3,2-b)(1,4)benzothiazine, 10-(3-(dimethylamino)propyl)-
CAS REGISTRY NUMBER :
303-69-5
BEILSTEIN REFERENCE NO. :
0259865
LAST UPDATED :
199706
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C16-H19-N3-S
MOLECULAR WEIGHT :
285.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 18,373,1963
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
415 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 8,489,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
135 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
STRAAA Strahlentherapie. (Urban & Schwarzenberg, Postfach 202440, D-8000 Munich 2, Fed. Rep. Ger.) V.1- 1912- Volume(issue)/page/year: 127,245,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
102 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 149,374,1964 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3040 mg/kg/22W-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,1709,1980 *** REVIEWS *** TOXICOLOGY REVIEW ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 4,263,1966

Safety Information

[ HS Code ]:
2934999090

Synthetic Route

Precursor & DownStream

Precursor

  • 1H-Pyrido[3,2-b][1,4]benzothiazine
  • 3-Chloro-N,N-dimethylpropan-1-amine
  • 2-[(3-NITRO-2-PYRIDINYL)SULFANYL]ANILINE
  • N-[2-(3-nitropyridin-2-yl)sulfanylphenyl]acetamide
  • 2-Aminothiophenol
  • 2-Anilinopyridine
  • Dimethylamine
  • 1-Bromo-3-chloropropane

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds

  • Prothipendyl HCl
  • Prothipendyl HCl
  • Prothipendyl Sulphoxide
  • Prothipendyl-d6 hydrochloride
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-[(2-methylfuran-3-yl)formamido]acetate
  • Tert-butyl 4-[(oxolan-2-yl)methyl]pyrrolidine-2-carboxylate
  • tert-butyl N-[2-amino-1-(1-benzothiophen-3-yl)ethyl]carbamate
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 4-(chloromethyl)-1-ethyl-5-(oxan-4-yl)-1H-1,2,3-triazole
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide