Hydralazine hydrochloride

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Names

[ CAS No. ]:
304-20-1

[ Name ]:
Hydralazine hydrochloride

[Synonym ]:
Asozart
HYDRALAZINE HYDROCHLORIDE
1-Hydrazinylphthalazine hydrochloride
Apulon
Phthalazine, 1-hydrazinyl-, hydrochloride (1:1)
1-hydrazinophthalazine hydrochloride
HYDRALAZINE MONOHYDROCHLORIDE
Lopres
EINECS 206-151-0
MFCD00135998
1-Hydrazinophthalazine hydrochloride (1:1)
Hyperazin
Hydrapress
1-hydrazinophtalazine chlorhydrate
Pressfall
1-hydrazinyl-Phthalazine hydrochloride
aiselazine
Apresoline
1-hydrazinylphthalazine hydrochloride (1:1)
hydrallazine hydrochloride
apresine
Dralzine
nor-press25
Hydralazine HCl
phthalazin-1-ylhydrazine hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
491.9ºC at 760 mmHg

[ Melting Point ]:
273°C

[ Molecular Formula ]:
C₈H₉ClN₄

[ Molecular Weight ]:
196.637

[ Flash Point ]:
251.3ºC

[ Exact Mass ]:
196.051575

[ PSA ]:
63.10000

[ LogP ]:
1.72400

[ Storage condition ]:
-20?C Freezer

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH9000000

CHEMICAL NAME :: Phthalazine, 1-hydrazino-, monohydrochloride

CAS REGISTRY NUMBER :: 304-20-1

LAST UPDATED :: 199806

DATA ITEMS CITED :: 28

MOLECULAR FORMULA :: C8-H8-N4.Cl-H

MOLECULAR WEIGHT :: 196.66

WISWESSER LINE NOTATION :: T66 CNNJ BMZ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 188 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 83 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 73 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 71 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 59 mg/kg/2D-I

TOXIC EFFECTS :: Endocrine - hyperglycemia Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in chlorine

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2950 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 176 mg/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1100 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1100 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 360 mg/kg

SEX/DURATION :: female 8-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 7500 ug/L

REFERENCE :: ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- Volume(issue)/page/year: (96),55,1978 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,85,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6128 No. of Facilities: 145 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 3818 (estimated) No. of Female Employees: 3142 (estimated)

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
TH9000000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2942000000

Precursor & DownStream

Precursor

DownStream

3-HYDROXYMETHYL-S-TRIAZOLO[3,4-A]PHTHALAZINE
s-Triazolo[3,4-a]phthalazine
3-methyl-1,2,4-triazolo[3,4-a]phthalazine
1(2H)-Phthalazinone
N'-(4-oxo-3H-phthalazin-1-yl)acetohydrazide
3-(D-galacto-pentitol-1-yl)-1,2,4-triazolo[3,4-a]phthalazine
N-(propan-2-ylideneamino)phthalazin-1-amine
N-phthalazin-1-ylphthalazin-1-amine
1,1-di(phthalazin-1-yl)hydrazine
1,1,2-tri(phthalazin-3-yl)hydrazine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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