2,7-Dioxaspiro[4.4]nonane-1,6-dione,3,8-dimethyl-

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Names

[ CAS No. ]:
3048-76-8

[ Name ]:
2,7-Dioxaspiro[4.4]nonane-1,6-dione,3,8-dimethyl-

[Synonym ]:
3,8-Dimethyl-2,7-dioxa-spiro[4.4]nonan-1,6-dion
3,8-Dimethyl-2,7-dioxaspiro(4.4)nonane-1,6-dione
2,7-DIOXASPIRO(4.4)NONANE-1,6-DIONE,3,8-DIMETHYL
2,2'-Spirobi(4-pentanolid)

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
409.9ºC at 760 mmHg

[ Molecular Formula ]:
C9H12O4

[ Molecular Weight ]:
184.18900

[ Flash Point ]:
220.9ºC

[ Exact Mass ]:
184.07400

[ PSA ]:
52.60000

[ LogP ]:
0.64360

[ Index of Refraction ]:
1.495

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JH4010000
CHEMICAL NAME :
2,7-Dioxaspiro(4.4)nonane-1,6-dione, 3,8-dimethyl-
CAS REGISTRY NUMBER :
3048-76-8
BEILSTEIN REFERENCE NO. :
0083942
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C9-H12-O4
MOLECULAR WEIGHT :
184.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>4 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 28,157,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3625 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 28,157,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal)
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 28,157,1976
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3070 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 28,157,1976

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • di-tert-butyl diallylmalonate
  • dimethyl 2,2-bis(prop-2-enyl)propanedioate
  • 3,8-bis(iodomethyl)-2,7-dioxaspiro[4.4]nonane-1,6-dione
  • methyl 2-cyano-2-prop-2-enylpent-4-enoate
  • 5,5-Diallylbarbituric acid
  • sodium 3-allyl-5-methyl-2-oxotetrahydrofuran-3-carboxylate
  • Diethyl diallylmalonate
  • Proxibarbal

DownStream

  • Bromoform

Related Compounds

  • 3-(2-bromoacetyl)-3,8-dimethyl-2,7-dioxaspiro[4.4]nonane-1,6-dione
  • 3,8-dimethylidene-2,7-dioxaspiro[4.4]nonane-1,6-dione
  • 2,7-Dioxaspiro[4.4]nonane-1,6-dione,3-[(dicyclohexylamino)methyl]-8-methyl-
  • 3-(anilinomethyl)-8-methyl-2,7-dioxaspiro[4.4]nonane-1,6-dione
  • 3,8-bis(iodomethyl)-2,7-dioxaspiro[4.4]nonane-1,6-dione
  • 3,8-bis(bromomethyl)-2,7-dioxaspiro[4.4]nonane-1,6-dione
  • N-(3-chlorophenyl)-2-[(2-methylquinazolin-4-yl)oxy]acetamide
  • N-(4-chlorophenyl)-2-[(2-methylquinazolin-4-yl)oxy]acetamide
  • N-(3-bromophenyl)-2-[(2-methylquinazolin-4-yl)oxy]acetamide
  • N-(4-bromophenyl)-2-[(2-methylquinazolin-4-yl)oxy]acetamide
  • N-(3-chloro-4-fluorophenyl)-2-[(2-methylquinazolin-4-yl)oxy]acetamide
  • N-(4-bromo-2-fluorophenyl)-2-[(2-methylquinazolin-4-yl)oxy]acetamide
  • 2-[(2-methylquinazolin-4-yl)oxy]-N-[3-(trifluoromethyl)phenyl]acetamide
  • N-(3-chloro-2-methylphenyl)-2-[(2-methylquinazolin-4-yl)oxy]acetamide
  • N-(5-chloro-2-methylphenyl)-2-[(2-methylquinazolin-4-yl)oxy]acetamide
  • N-(2-chloro-4-methylphenyl)-2-[(2-methylquinazolin-4-yl)oxy]acetamide