SANT-1

Suppliers

Names

[ Name ]:
SANT-1

[Synonym ]:
(E)-N-(4-Benzylpiperazin-1-yl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
SANT-1
(4-Benzyl-piperazin-1-yl)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-ylmethylene)-amine
Shh Signaling Antagonist V
(E)-N-(4-Benzyl-1-piperazinyl)-1-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methanimine
1-Piperazinamine (N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)
1-Piperazinamine, N-[(1E)-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-

Chemical & Physical Properties

[ Density]:
1.13g/cm3

[ Boiling Point ]:
547.4ºC at 760mmHg

[ Melting Point ]:
104-106ºC

[ Molecular Formula ]:
C₂₃H₂₇N₅

[ Molecular Weight ]:
373.49

[ Flash Point ]:
284.8ºC

[ Exact Mass ]:
373.22700

[ PSA ]:
36.66000

[ LogP ]:
3.51660

[ Index of Refraction ]:
1.623

[ Storage condition ]:
−20°C

[ Water Solubility ]:
Soluble in DMSO with warming

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Precursor & DownStream

Precursor

DownStream

Articles

Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

PLoS ONE 4(4) , e5182, (2009)

Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium up...

MicroRNA-602 and microRNA-608 regulate sonic hedgehog expression via target sites in the coding region in human chondrocytes.

Arthritis Rheumatology 67(2) , 423-34, (2015)

Hedgehog (HH) signaling has recently been associated with cartilage degradation in osteoarthritis (OA). Because interleukin-1β (IL-1β) has been implicated as a principal instigator of OA, we sought to...

MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.

FASEB J. 29 , 1817-29, (2015)

The Smoothened (Smo) receptor, a member of class F G protein-coupled receptors, is the main transducer of the Hedgehog (Hh) signaling pathway implicated in a wide range of developmental and adult proc...

Propane,1,1-bis(ethylsulfonyl)-2-methyl-
Pyridinium, 1- (2-hydroxy[1,1:3,1-terphenyl]-5-yl)-2,4, 6-triphenyl-, perchlorate (salt)
Cyclohexanecarboxylicacid, 1-methyl-3-oxo-, ethyl ester
2-[1-(2-hydroxy-3,5-dimethylphenyl)cyclohexyl]-4,6-dimethylphenol
3-[1-(2,5-dimethylthiophen-3-yl)octadecyl]-4-propan-2-ylideneoxolane-2,5-dione
trans-1,2-Dimethylcyclohexane
2-Amino-3-cyclopropylbutanoic acid
(2R)-4-chlorobutan-2-amine
tert-Butyl (2S,5R)-2-ethyl-4-(2-iodo-6-(methoxycarbonyl)pyridin-3-yl)-5-methylpiperazine-1-carboxylate
tert-Butyl (2S,5R)-2-ethyl-4-(6-(methoxycarbonyl)pyridin-3-yl)-5-methylpiperazine-1-carboxylate
3-(But-3-EN-2-YL)-1-methylthiourea
1-Formyl-1,2,3,4-tetrahydro-quinoline-6-sulfonic acid thiazol-2-ylamide
3-methyl-1H-indazole-5-sulfonyl chloride
N-(1,3-benzodioxol-5-yl)-2-[(3-ethyl[1,2,4]triazolo[4,3-b]pyridazin-6-yl)sulfanyl]acetamide
2-(3,3-dimethyl-2-oxobutyl)-6-(3-methoxyphenyl)pyridazin-3(2H)-one
I+/-,2,2-Trimethylcyclopropanepropanol