L-carnosine

Suppliers

Names

[ CAS No. ]:
305-84-0

[ Name ]:
L-carnosine

[Synonym ]:
(2S)-2-(3-aminopropanamido)-3-(1H-imidazol-5-yl)propanoic acid
N-b-Alanyl-L-histidine
EINECS 206-169-9
L-Histidine, N-β-alanyl-
β-Alanyl-L-histidine
N-(b-Alanyl)-L-histidine
N-β-Alanyl-L-histidin
beta-Alanyl-L-histidine
ignotine
n-2-m
L-IGNOTINE
carnosine
L-Histidine, N-(3-amino-1-hydroxypropylidene)-, (E)-
karnozzn
Carnosin
L-Carnosine
L-Histidine, β-alanyl-
MFCD00005207
N-β-Alanyl-L-histidine
(E)-N-(3-Amino-1-hydroxypropylidene)-L-histidine
Karnozin
H-β-Ala-His-OH

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
656.2±55.0 °C at 760 mmHg

[ Melting Point ]:
253 °C (dec.)(lit.)

[ Molecular Formula ]:
C₉H₁₄N₄O₃

[ Molecular Weight ]:
226.232

[ Flash Point ]:
350.7±31.5 °C

[ Exact Mass ]:
226.106583

[ PSA ]:
121.10000

[ LogP ]:
-2.17

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.591

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MS3080000

CHEMICAL NAME :: L-Histidine, N-beta-alanyl-

CAS REGISTRY NUMBER :: 305-84-0

BEILSTEIN REFERENCE NO. :: 0087671

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C9-H14-N4-O3

MOLECULAR WEIGHT :: 226.27

WISWESSER LINE NOTATION :: T5M CNJ D1YVQMV2Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >14930 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9087 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4446149 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 21 mg/kg

SEX/DURATION :: female 8-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,1219,1974

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
MS3080000

[ HS Code ]:
2933290090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1,3-thiazinane-2,6-dione
L-Histidine
(S)-2-(cyanoacetylamino)-3-(1H-imidazol-4-yl)propionic acid, sodium salt
rhodium
Carbon
(2S)-2-[3-(1,3-dioxoisoindol-2-yl)propanoylamino]-3-(1H-imidazol-5-yl)propanoic acid
beta-Alanine

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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