2,6-Diiodo-4-nitrophenol

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Names

[ CAS No. ]:
305-85-1

[ Name ]:
2,6-Diiodo-4-nitrophenol

[Synonym ]:
2,6-Diiodo-4-nitro-phenol
DNP
Phenol, 2,6-diiodo-4-nitro-
Phenol,2,6-diiodo-4-nitro
Diisophenol
MFCD00007335
DISOPHENOL
EINECS 206-170-4
Ancylol
Disofen
2,6-diodo-4-nitrophenol
2,6-diiod-4-nitrophenol
2,6-Diiodo-4-nitrophenol
2,5-DIHYDRO-1-(2-NITROPHENYL)-5-OXO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID HYDRAZIDE
Iodofen
4-nitro-2,6-diidophenol
Syngamix

Chemical & Physical Properties

[ Density]:
2.7±0.1 g/cm3

[ Boiling Point ]:
310.6±42.0 °C at 760 mmHg

[ Melting Point ]:
152-154 °C(lit.)

[ Molecular Formula ]:
C₆H₃I₂NO₃

[ Molecular Weight ]:
390.902

[ Flash Point ]:
141.6±27.9 °C

[ Exact Mass ]:
390.820221

[ PSA ]:
66.05000

[ LogP ]:
3.37

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.782

[ Stability ]:
Stable.

[ Water Solubility ]:
very sparingly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL0750000

CHEMICAL NAME :: Phenol, 2,6-diiodo-4-nitro-

CAS REGISTRY NUMBER :: 305-85-1

BEILSTEIN REFERENCE NO. :: 2052233

LAST UPDATED :: 199803

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C6-H3-I2-N-O3

MOLECULAR WEIGHT :: 390.90

WISWESSER LINE NOTATION :: WNR DQ CI EI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 170 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,232,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,232,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,232,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 105 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,232,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 212 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,232,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 107 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,232,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,232,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 6,232,1964

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 17,108,1973

Safety Information

[ Hazard Codes ]:
T:Toxic;Xn:Harmful;

[ Risk Phrases ]:
R20/21/22;R25;R36/37/38

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S28A

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
SL0750000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2908999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Nitrophenol
Phenol
Salicylic acid, 5-nitro-
p-Iodoxynitrobenzene
Sodium benzenolate
2,4,6-Triiodophenol
2-hydroxy-5-nitrobenzenesulphonic acid
1-Iodo-4-nitrobenzene
2,6-diiodophenol
Ammonia

DownStream

1,3-Diiodo-2-methoxy-5-nitrobenzene
4-amino-2,6-diiodophenol
4-amino-2-iodophenol
2,6-DIIODO-P-BENZOQUINONE
2,6-diiodophenol

Customs

[ HS Code ]: 2908999090

[ Summary ]:
2908999090 halogenated, sulphonated, nitrated or nitrosated derivatives of phenols or phenol-alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Related Compounds

2,6-DIIODO-4-NITROPHENOL
sodium,2,6-diiodo-4-nitrophenolate
2,6-Diiodo-4-(trifluoromethyl)anisole
2,6-Diiodo-4-(trifluoromethyl)aniline
2,6-diiodo-4-methyl-1,2,6-triarsabicyclo[2.2.1]heptane
2,6-DIIODO-4-NITROANILINE
3-(5-Bromo-2-chloropyridin-4-yl)-2-hydroxypropanoic acid
1-(3-bromo-1-methyl-1H-indol-2-yl)-2,2-difluoroethan-1-one
2-Fluoro-3-[(pyrrolidin-1-yl)methyl]pyridine
Methyl 6,6-dimethoxy-4-oxohexanoate
3-[2-(1-Aminocyclopropyl)ethyl]-4-bromobenzonitrile
rac-[(1R,3R)-3-(3-bromothiophen-2-yl)-2,2-dimethylcyclopropyl]methanamine
[1-(5-Bromo-2-cyclopropylpyrimidin-4-yl)-2-methylpropan-2-yl](methyl)amine
1-(4-Bromofuran-2-yl)-4,4-difluorocyclohexan-1-amine
4-(2-Bromo-6-methoxyphenyl)but-3-en-2-one
4-(3-bromo-1-methyl-1H-pyrazol-5-yl)butan-1-amine