SL-327

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Names

[ CAS No. ]:
305350-87-2

[ Name ]:
SL-327

[Synonym ]:
(2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
MEK1/2 Inhibitor
HMS3229K18
SL327
(2Z)-3-Amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]acrylonitrile
(Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-, (αZ)-
SL 327

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
512.6±50.0 °C at 760 mmHg

[ Melting Point ]:
127-128.2ºC

[ Molecular Formula ]:
C16H12F3N3S

[ Molecular Weight ]:
335.347

[ Flash Point ]:
263.8±30.1 °C

[ Exact Mass ]:
335.070404

[ PSA ]:
101.13000

[ LogP ]:
1.95

[ Appearance of Characters ]:
solid | white

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.631

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 32 mg/mL

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

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Oncogene 34 , 3985-93, (2015)

Oncolytic viruses exploit common molecular changes in cancer cells, which are not present in normal cells, to target and kill cancer cells. Ras transformation and defects in type I interferon (IFN)-me...

Repeated stimulation of dopamine D1-like receptor and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits.

Hippocampus 24(12) , 1466-81, (2014)

The acute activation of the dopamine D1-like receptors (D1R) is involved in a plethora of functions ranging from increased locomotor activity to the facilitation of consolidation, storage, and retriev...

Alcohol alters the activation of ERK1/2, a functional regulator of binge alcohol drinking in adult C57BL/6J mice.

Alcohol. Clin. Exp. Res. 39(3) , 463-75, (2015)

Binge alcohol drinking is a particularly risky pattern of alcohol consumption that often precedes alcohol dependence and addiction. The transition from binge alcohol drinking to alcohol addiction like...


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Related Compounds

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  • SL-651,498
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  • sl 84.0418