Deferiprone

Suppliers

Names

[ CAS No. ]:
30652-11-0

[ Name ]:
Deferiprone

[Synonym ]:
1,2-DIMETHYL-3-HYDROXYPYRID-4-ONE
3-hydroxy-1,2-dimethyl-pyrid-4-one
UNII-2BTY8KH53L
3-hydroxy-1,2-dimethylpyridin-4(1H)-one
Deferiprone
deferipnone
3-HYDROXY-1,2-DIMETHYL-4(1H)-PYRIDONE
Ferriprox
3-hydroxy-1,2-dimethyl-4-pyridinone
DMHP
DEFERIPRON
CP20
cp20(chelatingagent)
3-hydroxy-1,2-dimethyl-4-pyridone
1,2-dimethyl-3-hydroxy-4(1H)-pyridinone
3-Hydroxy-1,2-dimethyl-4(1H)-pyridinone
Kelfer
1,2-dimethyl-3-hydroxy-4-pyridinone
1,2-Dimethyl-3-hydroxy-4-pyridone
4(1H)-Pyridinone, 3-hydroxy-1,2-dimethyl-
Deferione
DEFERIDONE
MFCD00134497

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
232.7±40.0 °C at 760 mmHg

[ Melting Point ]:
272-275 °C(lit.)

[ Molecular Formula ]:
C7H9NO2

[ Molecular Weight ]:
139.152

[ Flash Point ]:
94.5±27.3 °C

[ Exact Mass ]:
139.063324

[ PSA ]:
42.23000

[ LogP ]:
-0.22

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.565

[ Storage condition ]:
-20°C Freezer

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UU7785940
CHEMICAL NAME :
4(1H)-Pyridinone, 1,2-dimethyl-3-hydroxy-
CAS REGISTRY NUMBER :
30652-11-0
BEILSTEIN REFERENCE NO. :
1447108
LAST UPDATED :
199803
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C7-H9-N-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Cardiac - other changes
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 18,202,1996
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 13,413,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
983 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO 63379) V.1- 1946- Volume(issue)/page/year: 76,2389,1990
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - food intake (animal) Gastrointestinal - ulceration or bleeding from stomach
REFERENCE :
BOMEEH BioMetals. (Rapid Communications of Oxford Ltd., The Old Malthouse, Paradise St., Oxford OX1 1LD, UK) V.5- 1992 Volume(issue)/page/year: 10,247,1997
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 18,202,1996 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4200 mg/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Endocrine - changes in thymus weight
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 28(Suppl A),73,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
52 gm/kg/52W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 28(Suppl A),81,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8400 mg/kg/4W-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Endocrine - changes in spleen weight Endocrine - changes in thymus weight
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 28(Suppl A),73,1992
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 gm/kg/12W-I
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified) Blood - changes in leukocyte (WBC) count Related to Chronic Data - death
REFERENCE :
BLOOAW Blood. (Grune & Stratton, Inc., 465 S. Lincoln Dr., Troy, MO 63379) V.1- 1946- Volume(issue)/page/year: 78,2727,1991
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
3600 mg/kg/28D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Related to Chronic Data - death
REFERENCE :
BOMEEH BioMetals. (Rapid Communications of Oxford Ltd., The Old Malthouse, Paradise St., Oxford OX1 1LD, UK) V.5- 1992 Volume(issue)/page/year: 10,247,1997
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
10500 mg/kg/35W-I
TOXIC EFFECTS :
Cardiac - cardiomyopathy including infarction Liver - hepatitis (hepatocellular necrosis), diffuse Blood - changes in leukocyte (WBC) count
REFERENCE :
BOMEEH BioMetals. (Rapid Communications of Oxford Ltd., The Old Malthouse, Paradise St., Oxford OX1 1LD, UK) V.5- 1992 Volume(issue)/page/year: 10,247,1997

Safety Information

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
3

[ RTECS ]:
UU7785940

[ HS Code ]:
2933399090

Synthetic Route

Precursor & DownStream

Precursor

  • Maltol
  • methylamine
  • 1,2-dimethyl-3-phenylmethoxypyridin-4-one
  • 3-(BENZYLOXY)-2-METHYL-4H-PYRAN-4-ONE
  • Methylamine hydrochloride
  • 1-(3-hydroxy-2-furyl)ethanone
  • galactosyl isomaltol
  • 3-hydroxy-1,2-dimethylpyridin-4(1H)-one acetate
  • (1,4-dihydro-1,2-dimethyl-4-oxo-pyridin-3-yl)β-D-glucopyranoside

DownStream

  • 3-hydroxy-1,2-dimethylpyridine-4-thione

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%


Related Compounds

  • Deferiprone-d3
  • Deferiprone-O-glucuronide
  • 3-((1-(Pyrazine-2-carbonyl)piperidin-3-yl)oxy)pyrazine-2-carbonitrile
  • 3-((1-(5-Methylisoxazole-3-carbonyl)piperidin-3-yl)oxy)pyrazine-2-carbonitrile
  • 3-((1-Picolinoylpiperidin-3-yl)oxy)pyrazine-2-carbonitrile
  • 3-((1-(Thiophene-3-carbonyl)piperidin-3-yl)oxy)pyrazine-2-carbonitrile
  • 3-((1-(4-Cyanobenzoyl)piperidin-3-yl)oxy)pyrazine-2-carbonitrile
  • 3-((1-(5-Chlorothiophene-2-carbonyl)piperidin-3-yl)oxy)pyrazine-2-carbonitrile
  • Ethyl (4-(azetidin-3-yloxy)phenyl)carbamate hydrochloride
  • 3-((1-(5-Cyclopropylisoxazole-3-carbonyl)piperidin-3-yl)oxy)pyrazine-2-carbonitrile
  • 3-((1-(2-(1H-pyrazol-1-yl)acetyl)piperidin-3-yl)oxy)pyrazine-2-carbonitrile
  • N-(2-(3-((3-cyanopyrazin-2-yl)oxy)piperidin-1-yl)-2-oxoethyl)-N-methylmethanesulfonamide
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