Hexamethylene bisacetamide

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Names

[ CAS No. ]:
3073-59-4

[ Name ]:
Hexamethylene bisacetamide

[Synonym ]:
N,N‘-Hexamethylenebisacetamide
N,N'-hexamethylene bis(acetamide)
Hexamethylenediacetamide
N,N'-diacetyl-1,6-hexanediamine
hmba
N,N′-Diacetyl-1,6-diaminohexane
diacetyldiaminohexane
EINECS 211-363-1
hexamethylenebis(acetamide)
N,N-Hexamethylenediacetamide
N,N'-DIACETYL-1,6-DIAMINOHEXANE
MFCD00008684

Chemical & Physical Properties

[ Density]:
0.974 g/cm3

[ Boiling Point ]:
456.7ºC at 760 mmHg

[ Melting Point ]:
128-129 °C(lit.)

[ Molecular Formula ]:
C10H20N2O2

[ Molecular Weight ]:
200.28

[ Flash Point ]:
193.2ºC

[ Exact Mass ]:
200.15200

[ PSA ]:
58.20000

[ LogP ]:
1.60080

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC2976200
CHEMICAL NAME :
Acetamide, N,N'-hexamethylenebis-
CAS REGISTRY NUMBER :
3073-59-4
BEILSTEIN REFERENCE NO. :
1775764
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H20-N2-O2
MOLECULAR WEIGHT :
200.32
WISWESSER LINE NOTATION :
1VM6MV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
4270 mg/kg/10D-C
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - thrombocytopenia
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 47,5788,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3250 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4100 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
INNDDK Investigational New Drugs. The Journal of New Anticancer Agents. Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018) V.1- 1983- Volume(issue)/page/year: 3,263,1985

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
R33:Danger of cumulative effects.

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
AC2976200

[ HS Code ]:
2924199090

Precursor & DownStream

Precursor

  • 1,6-Hexanediamine
  • Triethylamine
  • Acetyl chloride
  • Acetamide
  • acetic acid
  • 1,6-Diisocyanatohexane
  • Acetamide,N-2-propen-1-yl-
  • dilauroyl peroxide
  • 6-nitro-hexa-2,4-dienal O-methyl-oxime
  • Ethanoic anhydride

DownStream

  • N-Methylacetamide
  • Acetamide
  • Acetamide,N,N'-1,6-hexanediylbis[N-acetyl-
  • N,N-Dimethylacetamide
  • Acetamide,N,N'-hexamethylenebis[N-nitroso- (6CI,7CI,8CI)
  • N,N'-Diethyl-1,6-hexanediamine
  • Carbamic acid,N,N'-1,6-hexanediylbis-, C,C'-diethyl ester
  • Carbamic acid,N,N'-1,6-hexanediylbis-, 1,1'-bis(phenylmethyl) ester
  • Dimethyl hexane-1,6-diyldicarbamate
  • methyl 1,6-hexamethylenemonocarbamate monoacetamide

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

  • hexamethylene bis(chloroformate)
  • HEXAMETHYLENE SEBACATE POLYMER
  • hexamethylene bis(bromomagnesium)
  • hexamethylene bis(hydrogen sulphate), compound with N-ethyldibutylamine (1:2)
  • hexamethylene tetramine thiocyanate
  • Hexamethylene bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]
  • Ethyl 2-amino-2-(3-hydroxycyclopentyl)acetate
  • 4-(3,4-Dimethoxyphenyl)-6-(3,4-dimethylphenyl)pyrimidin-2-amine
  • 4-(3,4-Dimethylphenyl)-6-(furan-2-yl)pyrimidin-2-amine
  • 4-(2-Chlorophenyl)-6-(3,4-dimethylphenyl)pyrimidin-2-amine
  • 4-(3,4-Dimethylphenyl)-6-(4-ethoxyphenyl)pyrimidin-2-amine
  • 4-(3,4-Dimethylphenyl)-6-(3-nitrophenyl)pyrimidin-2-amine
  • 4-(4-tert-Butylphenyl)-6-(furan-2-yl)pyrimidin-2-amine
  • 4-(3-Nitrobenzoyl)-1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid
  • 1'-((Benzyloxy)carbonyl)-1-(tert-butoxycarbonyl)spiro[indoline-3,4'-piperidine]-6-carboxylic acid
  • 4-(3,5-Dinitrobenzoyl)-8-methyl-1-oxa-4-azaspiro[4.5]decane-3-carboxylic acid
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