CFTR(inh)-172

Suppliers

Names

[ Name ]:
CFTR(inh)-172

[Synonym ]:
CFTR INHIBITOR-172
Benzoic acid, 4-[(Z)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-
CFTR(inh)-172
4-[(Z)-{4-Oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid
4-[(E)-{4-Oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl]benzoic acid
Benzoic acid, 4-[(E)-[4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]-
4-[[4-Oxo-2-thioxo-3-[3-trifluoromethyl)phenyl]-5-thiazolidinylidene]methyl]benzoicacid
CFTRinh-172

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
555.7±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₀F₃NO₃S₂

[ Molecular Weight ]:
409.402

[ Flash Point ]:
289.9±32.9 °C

[ Exact Mass ]:
409.005432

[ PSA ]:
115.00000

[ LogP ]:
4.51

[ Appearance of Characters ]:
yellow

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.698

[ Storage condition ]:
Store at +4°C

[ Water Solubility ]:
DMSO: ≥10mg/mL

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H317-H319-H335-H410

[ Precautionary Statements ]:
P261-P273-P280-P305 + P351 + P338-P501

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi,N

[ Risk Phrases ]:
36/37/38-43-50/53

[ Safety Phrases ]:
26-36/37-60-61

[ RIDADR ]:
UN 3077 9 / PGIII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Thiazolidinone,2-thioxo-3-[3-(trifluoromethyl)phenyl]-
4-Formylbenzoic acid
3-(Trifluoromethyl)aniline
3-(trifluoromethyl)phenyl isothiocyanate

DownStream

Articles

Pseudomonas aeruginosa-induced bleb-niche formation in epithelial cells is independent of actinomyosin contraction and enhanced by loss of cystic fibrosis transmembrane-conductance regulator osmoregulatory function.

MBio 6 , e02533, (2015)

The opportunistic pathogen Pseudomonas aeruginosa can infect almost any site in the body but most often targets epithelial cell-lined tissues such as the airways, skin, and the cornea of the eye. A co...

Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis.

PLoS ONE 6 , e22212, (2011)

Evaluation of cystic fibrosis transmembrane conductance regulator (CFTR) functional activity to assess new therapies and define diagnosis of cystic fibrosis (CF) is cumbersome. It is known that leukoc...

Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.

J. Clin. Invest. 110 , 1651-1658, (2002)

Secretory diarrhea is the leading cause of infant death in developing countries and a major cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is requ...

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