Pyrazofurin

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Names

[ CAS No. ]:
30868-30-5

[ Name ]:
Pyrazofurin

[Synonym ]:
Pirazofurin
Pyrazofurin
Pyrazomycin

Chemical & Physical Properties

[ Density]:
1.786g/cm3

[ Boiling Point ]:
584.397ºC at 760 mmHg

[ Molecular Formula ]:
C9H13N3O6

[ Molecular Weight ]:
259.21600

[ Flash Point ]:
307.232ºC

[ Exact Mass ]:
259.08000

[ PSA ]:
161.92000

[ Index of Refraction ]:
1.718

[ Storage condition ]:
-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ6360000
CHEMICAL NAME :
1H-Pyrazole-5-carboxamide, 4-hydroxy-3-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
30868-30-5
LAST UPDATED :
199112
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C9-H13-N3-O6
MOLECULAR WEIGHT :
259.25
WISWESSER LINE NOTATION :
T5OTJ B1Q CQ DQ E- CT5MNJ DQ EVZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
108 mg/kg/5D
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
48 mg/kg/5D
TOXIC EFFECTS :
Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
84 mg/kg/5D
TOXIC EFFECTS :
Blood - changes in bone marrow (not otherwise specified) Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
108 mg/kg/5D
TOXIC EFFECTS :
Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Human
DOSE/DURATION :
144 mg/kg/5D
TOXIC EFFECTS :
Gastrointestinal - other changes Blood - changes in bone marrow (not otherwise specified) Skin and Appendages - dermatitis, other (after systemic exposure)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
70 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - dehydration
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - guinea pig Lymphocyte
DOSE/DURATION :
10 umol/L
REFERENCE :
JBTOEB Journal of Biochemical Toxicology. (VCH Publishers, Inc., 220 E. 23rd St., Suite 909, New York, NY USA 10010) V.1- 1986- Volume(issue)/page/year: 6,19,1991

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxamide
  • 2',3',5'-tri-O-acetylpyrazofurin
  • methyl 4-((3aS,6R,6aR)-2,2-dimethyl-6-((trityloxy)methyl)tetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-3-oxobutanoate
  • 4-hydroxy-5-(O2,O3-isopropylidene-α-D-ribofuranosyl)-1(2)H-pyrazole-3-carboxylic acid ethyl ester
  • 5-[O2,O3-isopropylidene-O5-(4-nitro-benzoyl)-α-D-ribofuranosyl]-4-oxo-4,5-dihydro-1H-pyrazole-3,5-dicarboxylic acid diethyl ester
  • 2-[O2,O3-isopropylidene-O5-(4-nitro-benzoyl)-α-D-ribofuranosyl]-3-oxo-pentanedioic acid diethyl ester
  • ethyl 4-hydroxy-3-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)pyrazole-5-carboxylate
  • methyl 2-diazo-4-(2,3-O-isopropylidene-5-O-trityl-α-D-ribofuranosyl)-3-oxobutanoate
  • 3(5)-cyano-4-hydroxy-5(3)-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazole
  • (2R,3R,4S,5S)-2-(acetoxymethyl)-5-(4-amino-5-cyano-1H-pyrazol-3-yl)tetrahydrofuran-3,4-diyl diacetate

DownStream

Related Compounds

  • 2',3'-O-isopropylidenepyrazofurin
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-(4-((1H-imidazol-4-yl)sulfonyl)-1,4-diazepan-1-yl)-2-(4-chlorophenoxy)ethanone
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide