2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethanol

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Names

[ Name ]:
2-[[1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl]amino]ethanol

[Synonym ]:
1-(3-trifluoromethyl phenyl)-2-(2-hydroxyethyl)-amino propane
2-({1-methyl-2-[3-(trifluoromethyl)phenyl]ethyl}amino)ethanol
4-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-pyridin-3-ylamine
1-(3-Amino-4-pyridyl)-4-(m-trifluoromethylphenyl)piperazine
1-(3-Trifluormethylphenyl)-4-(3-aminopyrid-4-yl)-piperazin
4-(m-Trifluoromethylphenyl)-1-(3-amino-4-pyridyl)piperazine
N-{2-[1-methyl-2-(3-trifluoromethyl)phenyl]ethyl}aminoethanol

Chemical & Physical Properties

[ Density]:
1.166g/cm3

[ Boiling Point ]:
317.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₂H₁₆F₃NO

[ Molecular Weight ]:
247.25700

[ Flash Point ]:
145.6ºC

[ Exact Mass ]:
247.11800

[ PSA ]:
32.26000

[ LogP ]:
2.60920

[ Index of Refraction ]:
1.475

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KL8235000

CHEMICAL NAME :: Ethanol, 2-(alpha-methyl-m-trifluoromethylphenethylamino)-

CAS REGISTRY NUMBER :: 31173-14-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H16-F3-N-O

MOLECULAR WEIGHT :: 247.29

WISWESSER LINE NOTATION :: Q2M1Y1&R CXFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 17XKAB "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970 Volume(issue)/page/year: -,21,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 184 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 17XKAB "International Symposium on Amphetamines and Related Compounds, Proceedings, Mario Negri Institute for Pharmacological Research, Milan, 1969," Costa, E., and S. Garattini, eds., New York, Raven Press, 1970 Volume(issue)/page/year: -,21,1970

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-(Trifluoromethyl)phenylacetone
2-Aminoethanol
ETHYLENE OXIDE
Phenethylamine, .α.-methyl-m-trifluoromethyl

DownStream

4-oxo-4-[2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethoxy]butanoic acid
Benfluorex
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl 4-aminobenzoate
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl 2-chlorobenzoate
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl 2-(4-chlorophenyl)acetate
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl cyclopropanecarboxylate
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl 4-fluorobenzoate
2-[1-[3-(trifluoromethyl)phenyl]propan-2-ylamino]ethyl propanoate

Related Compounds

2-Amino-2-[1-(4-methoxy-2-methylphenyl)cyclopropyl]acetic acid
2-Amino-2-[1-(2,2-dimethylpropyl)cyclopropyl]acetic acid
4-Amino-3-(2-methyl-5-nitrophenyl)butanoic acid
3-Amino-1-(2,3-difluorophenyl)cyclobutane-1-carboxylic acid
2-Amino-2-[1-(5-bromo-3-methylfuran-2-yl)cyclopropyl]acetic acid
4-Amino-1-(2,2,2-trifluoroethyl)cyclohexane-1-carboxylic acid
2-Amino-2-[1-(6-bromopyridin-3-yl)cyclopropyl]acetic acid
2-Amino-3-(5-bromopyrimidin-2-yl)-3-hydroxypropanoic acid
3-Amino-1-(2-chloro-5-methylphenyl)cyclobutane-1-carboxylic acid
4-Amino-4-[2-(methoxymethyl)-1,3-thiazol-4-yl]butanoic acid

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