Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-

Suppliers

Names

[ Name ]:
Acetamide,N-[(7S)-10-amino-5,6,7,9-tetrahydro-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-

[Synonym ]:
Colchicine amide
Colchicein-amid
Colchicamide
Colchiceinamide
Colchicamide (VAN)
(S)--7-Acetylamino-10-amino-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-on
N-((S)-10-amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
14-Aminocolchicide
10-demethoxy-10-N-aminocolchicine
Colchicamid
SKF 3192
Colchicenamide
Colchicide,14-amino
N-((S)-10-Amino-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid

Chemical & Physical Properties

[ Density]:
1.28g/cm3

[ Boiling Point ]:
722.2ºC at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₄N₂O₅

[ Molecular Weight ]:
384.42600

[ Flash Point ]:
390.6ºC

[ Exact Mass ]:
384.16900

[ PSA ]:
99.88000

[ LogP ]:
3.41730

[ Index of Refraction ]:
1.61

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0710000

CHEMICAL NAME :: Colchicine, 10-amino-10-demethoxy-

CAS REGISTRY NUMBER :: 3123-89-5

BEILSTEIN REFERENCE NO. :: 2824077

LAST UPDATED :: 199703

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C21-H24-N2-O5

MOLECULAR WEIGHT :: 384.47

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMV1 NZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29600 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 98,236,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 43 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 8900 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 160 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 85,235,1920 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 12 mg/kg/24D-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Gastrointestinal - nausea or vomiting Blood - changes in bone marrow (not otherwise specified)

REFERENCE :: CMJODS Chinese Medical Journal (Beijing, English Edition). (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1975- Adopted vol. no. 92 in 1979. Volume(issue)/page/year: 93,188,1980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Colchicine
Ammonia

DownStream

Related Compounds

3-(5-Fluoro-3-pyridinyl)-3-pyrrolidinol
2-Chloro-4-(ethylthio)-1-iodo-benzene
[1-(cyclobutylmethyl)-1H-pyrazol-4-yl]methanamine
[4-(tert-Butyl-dimethyl-silyloxy)-phenyl]-[6-(4-nitro-phenoxy)-pyrimidin-4-yl]-amine
1-[(5-Bromothiophen-2-yl)methyl]-1,3-diazaspiro[4.4]nonane-2,4-dione
3-((3-Cyano-6-methylpyridin-2-yl)amino)-N-propylpropanamide
3-[(1-Methoxypropan-2-yl)oxy]-2-methylpropane-1-sulfonyl chloride
1-Propanesulfonamide, 3-[[5-amino-6-(1-methylethoxy)-2-pyridinyl]amino]-
Pyrido[2,3-d]pyrimidine-3(2H)-acetamide, 1,4-dihydro-1-methyl-2,4-dioxo-N-[4-(2-phenyldiazenyl)phenyl]-7-(trifluoromethyl)-
4-(dimethylamino)-N-(2,2,2-trifluoroethyl)benzamide

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.