5-Methyl-1H-pyrazol-3-amine

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Names

[ Name ]:
5-Methyl-1H-pyrazol-3-amine

[Synonym ]:
3,5-AMP
3-methyl-5-amino-1H-pyrazole
5-METHYL-3-PYRAZOLAMINE
3-Methyl-1H-pyrazol-5-amine
MFCD00051640
1H-Pyrazol-3-amine, 5-methyl-
5-Methyl-1H-pyrazol-3-amine
5(3)-amino-3(5)-methylpyrazole
3-(methyl)-1H-pyrazol-5-amine
3-Amino-5-Methyl-1H-Pyrazole
5-amino-3-methylpyrazole
3(5)-amino-5(3)-methylpyrazole
3,1-AMP
5-Methylpyrazol-3-amine
(3-methyl-1H-pyrazol-5-yl)amine
3(5)-amino-5(3)-methyl-NH-pyrazole
5-Metyl-3-aminopyrazole

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
357.0±0.0 °C at 760 mmHg

[ Melting Point ]:
45-47 °C(lit.)

[ Molecular Formula ]:
C₄H₇N₃

[ Molecular Weight ]:
97.12

[ Flash Point ]:
169.5±9.5 °C

[ Exact Mass ]:
97.063995

[ PSA ]:
54.70000

[ LogP ]:
0.17

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.617

[ Storage condition ]:
-20?C Freezer

[ Stability ]:
Light Sensitive

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

3-aminocrotononitrile
but-2-ynenitrile
buta-2,3-dienenitrile
2,3-Dichloropropene
3-amino-2-butenenitrile
Triethyl orthoacetate
2-methyl-6-nitropyrazolo[1,5-a]pyrimidin-7(4H)-one
3-chlorobut-3-enenitrile
3-iminobutyronitrile
2-methyl-5,7-diphenyl-6,7-dihydropyrazolo[1,5-a]pyrimidine

DownStream

Tert-Butyl 5-Amino-3-Methyl-1H-Pyrazole-1-Carboxylate
1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester
2-methyl-5-phenyl-1H-pyrazolo[1,5-a]pyrimidin-7-one
2-methyl-5,7-diphenyl-6,7-dihydropyrazolo[1,5-a]pyrimidine
2-Methylpyrazolo[1,5-a]pyrimidin-5(4H)-one
Fast Red AL
2,5-Dimethylpyrazolo[1,5-a]pyrimidin-7-amine
2,5-Dimethylpyrazolo[1,5-a]pyrimidin-7-ol
2,5-Dimethylpyrazolo[1,5-a]pyrimidin-7(4H)-one

Articles

Interaction of ferrocenoyl-dipeptides with 3-aminopyrazole derivatives: beta-sheet models? A synthetic, spectroscopic, structural, and electrochemical study.

Inorg. Chem. 40(17) , 4409-19, (2001)

The use of 3-aminopyrazole derivatives as beta-sheet templates is investigated using a series of ferrocenoyl (Fc)-dipeptides (Fc-Gly(2)-OEt, Fc-Ala(2)-OBzl, Fc-Leu-Phe-OMe, Fc-Val-Phe-OMe, Fc-Phe(2)-O...

Characterization of peptide-pyrazole interactions in solution by low-temperature NMR studies.

Chemistry 13(3) , 854-61, (2007)

Complexation of the amino- and carboxyl-protected tripeptide Piv-L-Val-L-Val-L-Val-tBu with 3-methylpyrazole and 3-amino-5-methylpyrazole was studied by low-temperature NMR experiments in a freonic so...

Synthesis of partially hydrogenated pyrazolo [3, 4-b] quinolinones by condensation of 3-amino-5-methylpyrazole with aromatic aldehydes and dimedone. Lipson VV, et al.

Russ. J. Org. Chem. 42(7) , 1015-21, (2006)

4-iodo-5-methyl-1H-pyrazol-3-amine
1-ethyl-5-methyl-1H-pyrazol-3-amine
1-Butyl-5-methyl-1H-pyrazol-3-amine
4-bromo-5-methyl-1H-pyrazol-3-amine
1-Benzyl-5-methyl-1H-pyrazol-3-amine
4-Chloro-5-methyl-1H-pyrazol-3-amine
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
1-(2-Bromoethyl)-2,3,5-trifluorobenzene
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide