4-Benzylpiperidine

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Names

[ CAS No. ]:
31252-42-3

[ Name ]:
4-Benzylpiperidine

[Synonym ]:
4-Benzyl-piperidine
4-benzylpiperazine
4-benzylpyperidine
4-(phenylmethyl)piperidine
4-Benzylpiperidine
Piperidine,4-(phenylmethyl)
Piperidine,4-benzyl
EINECS 250-535-0
MFCD00006006
Phenyl(4-piperidyl)methane
α-(4-Piperidyl)toluene

Chemical & Physical Properties

[ Density]:
0.997 g/mL at 25 °C(lit.)

[ Boiling Point ]:
279 °C(lit.)

[ Melting Point ]:
6-7 °C(lit.)

[ Molecular Formula ]:
C12H17N

[ Molecular Weight ]:
175.27000

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
175.13600

[ PSA ]:
12.03000

[ LogP ]:
2.55750

[ Index of Refraction ]:
n20/D 1.537(lit.)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM4728000
CHEMICAL NAME :
Piperidine, 4-benzyl-
CAS REGISTRY NUMBER :
31252-42-3
BEILSTEIN REFERENCE NO. :
0132339
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H17-N
MOLECULAR WEIGHT :
175.30
WISWESSER LINE NOTATION :
T6MTJ D1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
56 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#01587

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TM4728000

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-benzyl-1-(4-methylphenyl)sulfonylpiperidine
  • 4-Benzylpyridine
  • 4-benzyl-1-methylsulfonylpiperidine
  • Piperidine
  • Benzaldehyde
  • Ethanol

DownStream

  • 2-Methyl-2-propanyl 4-(4-bromobenzyl)-1,4'-bipiperidine-1'-carbox ylate
  • 4-benzyl-1-(4-methylphenyl)sulfonylpiperidine
  • 4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]benzene-1,2-diamine
  • Phenyl carbamate
  • 4-benzyl-1-methylsulfonylpiperidine
  • 4-[(1-acetylpiperidin-4-yl)methyl]benzenesulfonyl chloride
  • 1-[4-[(4-methylsulfonylphenyl)methyl]piperidin-1-yl]ethanone
  • Pimetine
  • 1-[4-[(4-bromophenyl)methyl]-1-piperidyl]-2,2,2-trifluoro-ethanon e
  • 1-[4-(phenylmethoxy)phenyl]-2-[4-(phenylmethyl)piperidino]propan-1-one

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Selective suppression of cocaine- versus food-maintained responding by monoamine releasers in rhesus monkeys: benzylpiperazine, (+)phenmetrazine, and 4-benzylpiperidine.

J. Pharmacol. Exp. Ther. 329(1) , 272-81, (2009)

Monoamine releasers constitute one class of drugs currently under investigation as potential agonist medications for the treatment of cocaine dependence. The efficacy and safety of monoamine releasers...

Quantitative investigation on the metabolism of 1,3-butadiene and of its oxidized metabolites in once-through perfused livers of mice and rats.

Toxicol. Sci. 114(1) , 25-37, (2010)

The industrial chemical 1,3-butadiene (BD) is a potent carcinogen in mice and a weak one in rats. This difference is generally related to species-specific burdens by the metabolites 1,2-epoxy-3-butene...

Time-dependent inhibition of rat brain monoamine oxidase by an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine.

Neurosci. Lett. 70(2) , 255-60, (1986)

Inhibitory effects of some MPTP and MPP+ analogues on rat brain MAO activity were studied to further clarify the structure-activity relationships of MPTP neurotoxicity. Of the analogues tested, 4-(4-c...


More Articles

Related Compounds

  • N-methyl-4-benzylpiperidine
  • 1-acetyl-4-benzylpiperidine
  • 1-Butyryl-4-benzylpiperidine
  • 4-benzylpiperidine,hydrochloride
  • 4-benzylpiperidine-1-carboxamide
  • 4-benzylpiperidine,phosphoric acid
  • 1,6-Dimethyl-7-phenyl-1H-pyrazolo[5,1-b]purin-4(5H)-one
  • 1-(2-Methoxypyridin-4-yl)cyclobutane-1-carbonitrile
  • 1-(3-Bromopyridin-4-yl)cyclobutan-1-amine
  • 2-Amino-2-ethyl-5-fluoropentan-1-ol
  • 1-(6-Methylpyridin-2-yl)cyclobutane-1-carbonitrile
  • 1-(3-Chloropyridin-2-yl)cyclobutane-1-carbonitrile
  • 1-(1-ethyl-1H-imidazol-2-yl)cyclobutane-1-carbonitrile
  • 4-Chloro-2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepine
  • 1-(1-Methyl-1h-1,2,3-triazol-5-yl)cyclobutane-1-carbonitrile
  • 3-(2-Bromophenyl)-4-propylpyrrolidine
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