7-[2-(Diethylamino)ethyl]-1,3-dimethylxanthine
Suppliers
Names
[ CAS No. ]:
314-35-2
[ Name ]:
7-[2-(Diethylamino)ethyl]-1,3-dimethylxanthine
[Synonym ]:
Ditenate
ETAFEDRINE
2-[ethyl(methyl)amino]-1-phenylpropan-1-ol hydrochloride(1:1)
Etafedrine HCl
Etafedrine hydrochloride [USAN]
7-(2-Diaethylamino-aethyl)-1,3-dimethyl-3,7-dihydro-purin-2,6-dion
2-N-ethyl-N-methylamino-1-phenylpropanol hydrochloride
7-(2-diethylamino-ethyl)-1,3-dimethyl-3,7-dihydro-purine-2,6-dione
Etafedrine hydrochloride
etamiphylline
Nethamine
Nethamine (TN)
Soluphylline
7-[2-(diethylamino)ethyl]theophylline
Etafedrinhydrochlorid
Chemical & Physical Properties
[ Density]:
1.24g/cm3
[ Boiling Point ]:
460.2ºC at 760mmHg
[ Molecular Formula ]:
C13H21N5O2
[ Molecular Weight ]:
279.33800
[ Flash Point ]:
232.1ºC
[ Exact Mass ]:
279.17000
[ PSA ]:
65.06000
[ Index of Refraction ]:
1.605
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XH5095000
- CHEMICAL NAME :
- Theophylline, 7-(2-diethylamino)ethyl-
- CAS REGISTRY NUMBER :
- 314-35-2
- BEILSTEIN REFERENCE NO. :
- 0291098
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C13-H21-N5-O2
- MOLECULAR WEIGHT :
- 279.39
- WISWESSER LINE NOTATION :
- T56 BN DN FNVNVJ B2N2&2 F1 H1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - olfactory nerve change Behavioral - convulsions or effect on seizure threshold Cardiac - change in rate
- REFERENCE :
- HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 9,201,1990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1237 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,343,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 254 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,343,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 182 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,649,1954
Safety Information
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%