Nocodazole
Suppliers
Names
[ CAS No. ]:
31430-18-9
[ Name ]:
Nocodazole
[Synonym ]:
2-Benzimidazolecarbamic acid, 5-(2-thienylcarbonyl)-, methyl ester
Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate
methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate
Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
Nocodazole
Nocidazole
2-Benzimidazolecarbamic acid, 5-(2-thienoyl)-, methyl ester
Methyl 5-(2-thienoyl)-2-benzimidazolecarbamate
nocodazolum
Nocodazol
methyl [5-(thiophen-2-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate
EINECS 250-626-5
Carbamic acid, N-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-, methyl ester
Oncodazole
MFCD00005588
methyl 5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-ylcarbamate
Chemical & Physical Properties
[ Density]:
1.5±0.1 g/cm3
[ Melting Point ]:
300 °C (dec.)
[ Molecular Formula ]:
C14H11N3O3S
[ Molecular Weight ]:
301.320
[ Exact Mass ]:
301.052124
[ PSA ]:
112.32000
[ LogP ]:
2.43
[ Index of Refraction ]:
1.732
[ Storage condition ]:
2-8°C
[ Water Solubility ]:
DMSO: 10 mg/mL, soluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DD6521000
- CHEMICAL NAME :
- 2-Benzimidazolecarbamic acid, 5-(2-thenoyl)-, methyl ester
- CAS REGISTRY NUMBER :
- 31430-18-9
- LAST UPDATED :
- 199606
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C14-H11-N3-O3-S
- MOLECULAR WEIGHT :
- 301.34
- WISWESSER LINE NOTATION :
- T56 BM DNJ CMVO1 GV- BT5SJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 39530 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 10 mg/kg
- SEX/DURATION :
- female 1 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
- TEST SYSTEM :
- Mammal - species unspecified
- DOSE/DURATION :
- 2 ug/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 201,423,1988
Safety Information
[ Symbol ]:
GHS08
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H341-H361d
[ Precautionary Statements ]:
P281
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
R61
[ Safety Phrases ]:
S53-S45-S36/37/39-S26
[ RIDADR ]:
2811
[ WGK Germany ]:
3
[ RTECS ]:
DD6521000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2934999090
Synthetic Route
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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