(-)-Corey lactone 4-phenylbenzoate alcohol

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Names

[ Name ]:
(-)-Corey lactone 4-phenylbenzoate alcohol

[Synonym ]:
[1,1'-Biphenyl]-4-carboxylic acid, hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[b]furan-5-yl ester
Hexahydro-4-hydroxymethyl-5-(4-phenylbenzoyloxy)cyclopenta[b]furan-2-one
Corey's lactone
Corey lactone
MFCD00078077
(3aR,4S,5R,6aS)-4-(Hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl 4-Phenylbenzoate
4-(Hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl 4-biphenylcarboxylate
(3aR,4S,5R,6aS)-Hexahydro-4-(hydroxymethyl)-5-(4-phenylbenzoyloxy)-2H-cyclopenta[b]furan-2-one
(-)-Corey Lactone 4-Phenylbenzoate
(-)-Corey lactone 4-phenylbenzoate alcohol
4-(Hydroxymethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate
Corey lactone 4-phenylbenzoate
PPB-Corey-lactone

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
584.8±45.0 °C at 760 mmHg

[ Melting Point ]:
131-132 °C(lit.)

[ Molecular Formula ]:
C₂₁H₂₀O₅

[ Molecular Weight ]:
352.380

[ Flash Point ]:
210.6±22.2 °C

[ Exact Mass ]:
352.131073

[ PSA ]:
72.83000

[ LogP ]:
2.33

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.629

[ Storage condition ]:
2~8°C

[ Water Solubility ]:
insoluble

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Fluprostenol Lactone Diol
LatanoprostAcid
Latanoprost Lactol
Latanoprost
(-)-Corey lactone diol
(3AR,4S,5R,6AS)-4-(((TERT-BUTYLDIMETHYLSILYL)OXY)METHYL)-5-((TETRAHYDRO-2H-PYRAN-2-YL)OXY)HEXAHYDRO-2H-CYCLOPENTA[B]FURAN-2-ONE
Latanoprost lactone diol
[1,1'-Biphenyl]-4-carboxylic acid(3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2H-cyclopenta[b]furan-5-ylester
(15S)-Latanoprost Acid
[1,1'-Biphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-5-phenyl-1-pentenyl]-2H-cyclopenta[b]furan-5-yl ester

Articles

Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents.

J. Med. Chem. 36 , 243, (1993)

A series of phenyl-substituted analogues of prostaglandin F2 alpha (PGF2 alpha) were prepared and evaluated for ocular hypotensive effect and side effects in different animal models. In addition, the ...

Aldrichimica Acta 15 , 65, (1982)

(+)-corey lactone, 4-phenylbenzoate alcohol
(3AR,4R,5R,6aS)-5-Hydroxy-4-((S,E)-3-hydroxyoct-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2-one
(+/-)-COREY LACTONE, 5-(4-PHENYLBENZOATE)
(-)-Corey lactone diol
(-)-Corey lactone benzoate
(-)-Corey lactone-heptyldioxolane-d15
methyl {[1-(naphthalen-2-ylmethyl)-1H-benzimidazol-2-yl]methyl}carbamate
benzyl ((1H-benzo[d]imidazol-2-yl)methyl)(methyl)carbamate
methyl ((1-(2-chloro-6-fluorobenzyl)-1H-benzo[d]imidazol-2-yl)methyl)(methyl)carbamate
methyl methyl((1-(2-morpholino-2-oxoethyl)-1H-benzo[d]imidazol-2-yl)methyl)carbamate
4-amino-5-(4-(dimethylamino)phenyl)-2-(ethylthio)-8,8-dimethyl-7,8,9,10-tetrahydropyrimido[4,5-b]quinolin-6(5H)-one
2-propylindeno[1,2,3-de]phthalazin-3(2H)-one
N-(2-ethoxyphenyl)-2-((1-(2-(trifluoromethyl)phenyl)-1H-tetrazol-5-yl)thio)acetamide
N-(propan-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}sulfanyl)acetamide
1-morpholino-2-((1-(3-(trifluoromethyl)phenyl)-1H-tetrazol-5-yl)thio)ethanone
N-allyl-2-((1-(2-(trifluoromethyl)phenyl)-1H-tetrazol-5-yl)thio)acetamide

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