1-(2,6-Dimethylphenoxy)-2-propanamine

Names

[ CAS No. ]:
31828-71-4

[ Name ]:
1-(2,6-Dimethylphenoxy)-2-propanamine

[Synonym ]:
Ko 1173Cl
mexitil
Cirumimeru
EINECS 250-825-7
ko1173
Katen
MFCD00216024
Ritalmex
1-(2,6-Dimethylphenoxy)-2-propanamine
Mexilitene
Olzoron
MEXILITINE HCL
Toy

Chemical & Physical Properties

[ Density]:
0.979 g/cm3

[ Boiling Point ]:
271.5ºC at 760 mmHg

[ Melting Point ]:
203-205ºC

[ Molecular Formula ]:
C11H17NO

[ Molecular Weight ]:
179.25900

[ Flash Point ]:
112.2ºC

[ Exact Mass ]:
179.13100

[ PSA ]:
35.25000

[ LogP ]:
2.72970

[ Appearance of Characters ]:
powder | white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
ethanol: 50 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KR9300000
CHEMICAL NAME :
Ethylamine, 1-methyl-2-(2,6-xylyloxy)-
CAS REGISTRY NUMBER :
31828-71-4
LAST UPDATED :
199703
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H17-N-O
MOLECULAR WEIGHT :
179.29
WISWESSER LINE NOTATION :
ZY1&1OR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human
DOSE/DURATION :
63 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Gastrointestinal - nausea or vomiting
REFERENCE :
PMESAJ Postgraduate Medical Journal, Supplement. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1949- Volume(issue)/page/year: 53(Suppl 1),134,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
349 mg/kg/4D-I
TOXIC EFFECTS :
Blood - thrombocytopenia
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 100,162,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
41 mg/kg
TOXIC EFFECTS :
Toxic effects not yet reviewed
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #5116974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DECRDP Drugs under Experimental and Clinical Research. (Bioscience Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977- Volume(issue)/page/year: 13,21,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
114 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction)
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 21,370,1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 41,1130,1991

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S36

[ RIDADR ]:
UN 3249

[ WGK Germany ]:
3

[ RTECS ]:
KR9300000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2922299090

Precursor & DownStream

Precursor

  • N-BOC-2-(2,6-dimethylphenoxy)-1-methylethylamine
  • 1-(2,6-Dimethylphenoxy)-2-azido-propan
  • Mexiletine hydrochloride
  • 1-(2,6-dimethylphenoxy)propan-2-one
  • 2,6-Xylenol
  • 1-(2,6-DICHLOROPHENYL)BIGUANIDEHYDROCHLORIDE
  • 1-(2,6-Dimethylphenoxy)-2-methansulfonyloxy-propan
  • 2-Methylaziridine

DownStream

  • 1-(2,6-dimethylphenoxy)propan-2-one
  • S-(+)-Mexiletine
  • 1-(2,6-Dimethylphenoxy)-2-propanamine

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 1-(2,6-Dimethylphenoxy)-2-Propanamine
  • 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride (1:1)
  • 1-(2,6-Dimethylphenoxy)-2-methansulfonyloxy-propan
  • 1-(2,6-dimethylphenoxy)-2-(3,4-dimethoxyphenylethylamino)propane
  • 1-(2,6-dimethylphenoxy)-2,4-dinitronaphthalene
  • 1-(2,6-Dimethylphenoxy)-2-azido-propan