Indoprofen
Suppliers
Names
[ CAS No. ]:
31842-01-0
[ Name ]:
Indoprofen
[Synonym ]:
Praxis
α-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
INDOPROFEN
flosin
Bor-ind
Reumofe
isindone
flosint
k4277
Reumofene
Chemical & Physical Properties
[ Density]:
1.308g/cm3
[ Boiling Point ]:
511.3ºC at 760mmHg
[ Melting Point ]:
213-214°
[ Molecular Formula ]:
C17H15NO3
[ Molecular Weight ]:
281.30600
[ Flash Point ]:
263ºC
[ Exact Mass ]:
281.10500
[ PSA ]:
57.61000
[ LogP ]:
3.10010
[ Index of Refraction ]:
1.642
[ Storage condition ]:
2-8℃
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MU6645000
- CHEMICAL NAME :
- Hydratropic acid, p-(1-oxo-2-isoindolinyl)-
- CAS REGISTRY NUMBER :
- 31842-01-0
- LAST UPDATED :
- 199309
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C17-H15-N-O3
- MOLECULAR WEIGHT :
- 281.33
- WISWESSER LINE NOTATION :
- T56 BVN DHJ CR DY1&VQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 84 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1100,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 23,1100,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 375 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Behavioral - ataxia
- REFERENCE :
- FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,1037,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 84 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 112,291,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 38320 mg/kg/68W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes primarily in glomeruli Kidney, Ureter, Bladder - interstitial nephritis Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,742,1982
Safety Information
[ Symbol ]:
GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H351
[ Precautionary Statements ]:
P281-P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
25-40
[ Safety Phrases ]:
22-36/37/39-45
[ RIDADR ]:
UN 2811 6.1 / PGIII
[ WGK Germany ]:
3
[ RTECS ]:
MU6645000
[ HS Code ]:
2918300090
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2918300090
[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%
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A generic chiral separation strategy for the analysis of acidic compounds in CEC is proposed in completion of an earlier defined strategy for nonacidic compounds. The screening step of this strategy u...
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