Axitinib

Suppliers

Names

[ CAS No. ]:
319460-85-0

[ Name ]:
Axitinib

[Synonym ]:
N-Methyl-2-({3-[(E)-2-(2-pyridinyl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide
Benzamide, N-methyl-2-[[3-[(E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-
UNII-C9LVQ0YUXG
Inlyta
Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-
10mg
Axitinib (usan)
N-Methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide
AG-013736 N-Methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide
Axtinib
AVERMECTINB
Axitinib
N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
[14C]-Axitinib

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
668.9±55.0 °C at 760 mmHg

[ Melting Point ]:
213-215ºC

[ Molecular Formula ]:
C₂₂H₁₈N₄OS

[ Molecular Weight ]:
386.470

[ Flash Point ]:
358.3±31.5 °C

[ Exact Mass ]:
386.120117

[ PSA ]:
95.97000

[ LogP ]:
4.15

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.728

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H400

[ Precautionary Statements ]:
P273

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-50/53

[ Safety Phrases ]:
60-61

[ RIDADR ]:
UN 3077 9 / PGIII

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

2-Vinylpyridine
2-((3-IODO-1H-INDAZOL-6-YL)THIO)-N-METHYLBENZAMIDE

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3B1 (HS3ST3B1) promotes angiogenesis and proliferation by induction of VEGF in acute myeloid leukemia cells.

J. Cell. Biochem. 116(6) , 1101-12, (2015)

Heparan sulfate (HS) are complex polysaccharides that reside on the plasma membrane of almost all mammalian cells, and play an important role in physiological and pathological conditions. Heparan sulf...

Involvement of corneal lymphangiogenesis in a mouse model of allergic eye disease.

Invest. Ophthalmol. Vis. Sci. 56 , 3140-8, (2015)

The contribution of lymphangiogenesis (LA) to allergy has received considerable attention and therapeutic inhibition of this process via targeting VEGF has been considered. Likewise, certain inflammat...

Chronic inflammation, lymphangiogenesis, and effect of an anti-VEGFR therapy in a mouse model and in human patients with aspiration pneumonia.

J. Pathol. 235(4) , 632-45, (2015)

Chronic inflammation induces lymphangiogenesis and blood vessel remodelling. Since aged pneumonia patients often have repeated episodes of aspiration pneumonia, the pathogenesis may involve chronic in...

Axitinib-d3
Axitinib Amide
Axitinib-13C-d3
AXITINIB SULFOXIDE
Axitinib Impurity 3
Axitinib Impurity b
4-Chloro-1-nitro-2-propoxybenzene
(1S,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2-carboxylic acid
Agaricoglyceride A
(3R,4R)-3,4-dihydroxy-3,4-dihydrochromen-2-one
Tert-butyl 2,3-dihydrothiophene-3-carboxylate
(4aR,5R,7aS)-Hexahydro-5-phenyl-2H-furo[3,4-b]pyran
7-chloro-3-hydroxybenzo[d][1,2,3]triazin-4(3H)-one
(R)-1-(4-Chlorophenyl)-2-azidoethanol
Cyclohexanecarboxamide,n-5-pyrimidinyl-
(R)-1-Para-nitro-phenyl-2-azido-ethanol

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