3,5-Dichloro-2-hydroxybenzoic acid

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Names

[ CAS No. ]:
320-72-9

[ Name ]:
3,5-Dichloro-2-hydroxybenzoic acid

[Synonym ]:
3,5-Cl2salH
3,5-Dichlorosalicylic acid
Salicylic acid,3,5-dichloro
Benzoic acid,3,5-dichloro-2-hydroxy
USAF DO-68
Benzoic acid, 3,5-dichloro-2-hydroxy-
EINECS 206-281-8
2-Hydroxy-3,5-dichlorobenzoic acid
3,5-dichloro-2-hydroxy-benzoic acid
3,5-Dichloro-2-hydroxybenzoic acid
MFCD00002442

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
319.3±42.0 °C at 760 mmHg

[ Melting Point ]:
221-224 °C

[ Molecular Formula ]:
C7H4Cl2O3

[ Molecular Weight ]:
207.011

[ Flash Point ]:
146.9±27.9 °C

[ Exact Mass ]:
205.953751

[ PSA ]:
57.53000

[ LogP ]:
4.40

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.641

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VO2450000
CHEMICAL NAME :
Salicylic acid, 3,5-dichloro-
CAS REGISTRY NUMBER :
320-72-9
BEILSTEIN REFERENCE NO. :
2210803
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H4-Cl2-O3
MOLECULAR WEIGHT :
207.01
WISWESSER LINE NOTATION :
QVR BQ CG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VO2450000

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Salicylic acid
  • 3,5-Dichloro-2-hydroxybenzoic acid methyl ester
  • 3,5-dichloro-2-[9]phenanthrylmethoxy-benzoic acid
  • 2-benzyloxy-3,5-dichloro-benzoic acid methyl ester
  • 3,5-dichloro-2-[9]phenanthrylmethoxy-benzoic acid methyl ester
  • 5-chlorosalicylic acid
  • Sulfosalicylic Acid
  • 3,5-dichloro-2-iodobenzoic acid

DownStream

  • 6-Bromo-2,4,5-trichlorophenol
  • 3,5,6-Trichlorosalicylic acid
  • 2,4-dichloro-6-iodophenol
  • bis(2-butoxycarbonyl-3,4,6-trichlorophenyl) oxalate
  • Benzamide,3,5-dibromo-2-hydroxy-N-phenyl-
  • pentyl 3,5,6-trichlorosalicylate
  • 2,4,5-Trichlorophenol
  • 2,4-Dichloro-6-nitrophenol
  • 2,3,4,6-TETRACHLOROPHENOL
  • phenyl 3,5-dichloro-2-hydroxybenzoate

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Spectral deciphering of the interaction between an intramolecular hydrogen bonded ESIPT drug, 3,5-dichlorosalicylic acid, and a model transport protein.

Phys. Chem. Chem. Phys. 14(25) , 8892-902, (2012)

The present work demonstrates a detailed characterization of the interaction of a bio-active drug molecule 3,5-dichlorosalicyclic acid (3,5DCSA) with a model transport protein Bovine Serum Albumin (BS...

Structure of aldehyde reductase in ternary complex with coenzyme and the potent 20alpha-hydroxysteroid dehydrogenase inhibitor 3,5-dichlorosalicylic acid: implications for inhibitor binding and selectivity.

Arch. Biochem. Biophys. 479(1) , 82-7, (2008)

The structure of aldehyde reductase (ALR1) in ternary complex with the coenzyme NADPH and 3,5-dichlorosalicylic acid (DCL), a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1), w...


More Articles

Related Compounds

  • 3,5-Dichloro-2-hydroxybenzoic acid methyl ester
  • 3,5-dichloro-4-fluoro-2-hydroxybenzoic acid
  • 4,5-dichloro-2-hydroxybenzoic acid
  • 3-(3,5-dichloro-N-pyridin-4-ylanilino)-1-morpholin-4-ylpropan-1-one,2-hydroxybenzoic acid
  • ZL006
  • 3,5-dichloro-2-nitrobenzoic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 4-[4-(3-chlorophenyl)piperazin-1-yl]-6-(1H-imidazol-1-yl)pyrimidine
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide