Sulindac Sulfide

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Names

[ CAS No. ]:
32004-67-4

[ Name ]:
Sulindac Sulfide

[Synonym ]:
MFCD00869764
{(1Z)-5-Fluoro-2-methyl-1-[4-(methylsulfanyl)benzylidene]-1H-inden-3-yl}acetic acid
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-
EINECS 250-892-2
SULINDAC SULFIDE
5-fluoro-2-methyl-1-(4-methylthiobenzylidene)inden-3-ylacetic acid ; [Sulindac Sulfide ]
5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
526.3±50.0 °C at 760 mmHg

[ Melting Point ]:
189-191°C

[ Molecular Formula ]:
C₂₀H₁₇FO₂S

[ Molecular Weight ]:
340.411

[ Flash Point ]:
272.1±30.1 °C

[ Exact Mass ]:
340.093323

[ PSA ]:
62.60000

[ LogP ]:
5.74

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.653

[ Water Solubility ]:
DMSO: >22 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H317-H334-H361

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22;R42/43;R63

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Capping of aβ42 oligomers by small molecule inhibitors.

Biochemistry 53(50) , 7893-903, (2014)

Aβ42 peptides associate into soluble oligomers and protofibrils in the process of forming the amyloid fibrils associated with Alzheimer's disease. The oligomers have been reported to be more toxic to ...

Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers.

Drug Metab. Pharmacokinet. 30(1) , 70-4, (2015)

Human flavin-containing monooxygenase 3 (FMO3) in the liver catalyzes a variety of oxygenations of nitrogen- and sulfur-containing medicines and xenobiotic substances. Because of growing interest in d...

Sulindac sulfide--induced stimulation of eryptosis.

Cell Physiol. Biochem. 30(4) , 1072-82, (2012)

Sulindac sulfide, a non-steroidal anti-inflammatory drug (NSAID), stimulates apoptosis of tumor cells and is thus effective against malignancy. In analogy to apoptosis of nucleated cells, erythrocytes...