2-fluoronaphthalene

Names

[ CAS No. ]:
323-09-1

[ Name ]:
2-fluoronaphthalene

[Synonym ]:
2-Fluoro-naphthalene
Naphthalene,2-fluoro
EINECS 206-299-6
MFCD00082618
2-F-naphthalene
2-fluoronaphtalene

Chemical & Physical Properties

[ Density]:
1.144 g/cm3

[ Boiling Point ]:
225.9ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₇F

[ Molecular Weight ]:
146.16100

[ Flash Point ]:
65 °C

[ Exact Mass ]:
146.05300

[ LogP ]:
2.97890

MSDS

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T: Toxic;Xn: Harmful;

[ Risk Phrases ]:
R45

[ Safety Phrases ]:
S53-S23-S24/25-S36/37

[ RIDADR ]:
UN 1593 6.1/PG 3

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Naphthyl trifluoromethanesulfonate
1-Chloronaphthalene
6-Fluoro-1-naphthoic acid
Naphthalene
Dichloromonofluoromethane
Indene
2-IODONAPHTHALENE
2-Bromonaphthalene
2-(TRIMETHYLSILYL)NAPHTHALENE

DownStream

2-Naphthyl acetate
2-Naphthyl benzoate
6-Fluoro-2-naphthalenesulfonyl chloride
2-phenylnaphthalene-1-carboxylic acid
3-phenyl-2-naphthioc acid
1-phenylnaphthalene-2-carboxylic acid
2-Ethoxy-1-nitronaphthalene
2-Fluoro-1-naphthalenecarboxaldehyde
3-Fluoro-naphthalene-2-carboxaldehyde
2-fluoro-1-methylnaphthalene

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Quantitative structure-activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme.

J. Med. Chem. 48 , 440-9, (2005)

The purpose of this study was to develop screening and in silico modeling methods to obtain accurate information on the active center of CYP2A6, a nicotine oxidizing enzyme. The inhibitory potencies o...

Exploring QSAR and QAAR for inhibitors of cytochrome P450 2A6 and 2A5 enzymes using GFA and G/PLS techniques

Eur. J. Med. Chem. 44 , 1941-51, (2009)

A series of naphthalene and non-naphthalene derivatives ( n = 42) having cytochrome P450 2A6 and 2A5 inhibitory activities, reported by Rahnasto et al., were subjected to QSAR and QAAR studies. The an...

Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors.

J. Med. Chem. 48 , 3808-15, (2005)

The purpose of this study was to determine the cytochrome P450 1A2 (CYP1A2) inhibition potencies of structurally diverse compounds to create a comprehensive three-dimensional quantitative structure-ac...