2,4,6(1H,3H,5H)-Pyrimidinetrione,5,5-dihydroxy-

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Names

[ CAS No. ]:
3237-50-1

[ Name ]:
2,4,6(1H,3H,5H)-Pyrimidinetrione,5,5-dihydroxy-

[Synonym ]:
5,5-Dihydroxyperhydropyrimidinetrione
EINECS 221-796-8
alloxane hydrate
Alloxan hydrate
Barbituric acid,5,5-dihydroxy
alloxan monohydrate
5,5-dihydroxy-pyrimidine-2,4,6-trione

Chemical & Physical Properties

[ Density]:
1.99g/cm3

[ Molecular Formula ]:
C4H4N2O5

[ Molecular Weight ]:
160.08500

[ Exact Mass ]:
160.01200

[ PSA ]:
115.73000

[ Index of Refraction ]:
1.63

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CQ4004800
CHEMICAL NAME :
Barbituric acid, 5,5-dihydroxy-
CAS REGISTRY NUMBER :
3237-50-1
BEILSTEIN REFERENCE NO. :
0155548
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C4-H4-N2-O5
MOLECULAR WEIGHT :
160.10

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
40 mg/kg
SEX/DURATION :
female 1 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - biochemical and metabolic

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
2490 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 13,60,1989

Safety Information

[ HS Code ]:
2933540000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Barbituric acid
  • 5-Bromouracil
  • Uracil
  • Uric Acid
  • Chlorine
  • acetic acid

DownStream

  • Alloxazine;Isoalloxazine
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione,5,5-diphenyl-
  • N-carbamoyl-2,2-diphenyl-acetamide
  • 2-amino-4,6-dioxo-4a,5-dihydropteridine-7-carboxylic acid
  • 2-amino-4,7-dioxo-1,8-dihydropteridine-6-carboxylic acid
  • [5,5'-Bipyrimidine]-2,2',4,4',6,6'(1H,1'H,3H,3'H,5H,5'H)-hexone,5,5'-dihydroxy-
  • Benzo[g]pteridine-2,4(1H,3H)-dione, 10-(2-hydroxyethyl)-
  • LUMICHROME
  • 5-hydroxy-5-(2-hydroxy-6-oxo-1-cyclohexenyl)-1,3-diazinane-2,4,6-trione
  • Hydrazinecarbothioamide,2-(tetrahydro-2,4,6-trioxo-5(2H)-pyrimidinylidene)-

Customs

[ HS Code ]: 2933540000

[ Summary ]:
2933540000 other derivatives of malonylurea (barbituric acid); salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

Related Compounds

  • 2,4,6(1H,3H,5H)-Pyrimidinetrione,5,5-diethyl-1-phenyl-
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[(5-methoxy-1H-indol-3-yl)methyl]-1,3-dimethyl
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[(5-methoxy-1H-indol-3-yl)methylene]-1,3-dimethyl
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione,5,5-diphenyl-
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione,5-[[5-(diethylamino)-2-furanyl]methylene]-1-(3-fluorophenyl)-
  • 2,4,6(1H,3H,5H)-Pyrimidinetrione,5,5-diethyl-1-(1-piperidinylmethyl)-
  • 4-({[(5-bromo-1H-indol-1-yl)acetyl]amino}methyl)benzoic acid
  • N-(4-bromo-2-fluorophenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide
  • 3-Phenyl-1,2-benzoxazol-6-yl 3,4,5-trimethoxybenzoate
  • 2-(7-methoxy-1H-indol-1-yl)-N-(2-phenylethyl)acetamide
  • 6-[(6-chloro-4H-1,3-benzodioxin-8-yl)methoxy]-3-phenyl-1,2-benzoxazole
  • [6-Isopropyl-2-(3-pyridyl)-4-quinolyl](1,4-thiazinan-4-yl)methanone
  • N-(2-fluorobenzyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-7-carboxamide
  • N-(1,3-benzodioxol-5-ylmethyl)-4-(piperidin-1-yl)pteridin-2-amine
  • N-(4-{[4-(1H-indol-1-ylacetyl)piperazin-1-yl]sulfonyl}phenyl)acetamide
  • ethyl (2-{[3-(6,7-dimethoxy-4-oxoquinazolin-3(4H)-yl)propanoyl]amino}-1,3-thiazol-4-yl)acetate
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