4-Fluorobiphenyl

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Names

[ CAS No. ]:
324-74-3

[ Name ]:
4-Fluorobiphenyl

[Synonym ]:
P-FLUOROBIPHENYL
Biphenyl,4-fluoro
p-Fluorodiphenyl
MFCD00011650
F-BIPHENYL
4-fluoro-bipheny
4-Fluoro-biphenyl
4-FLUORODIPHENYL
1,1'-Biphenyl, 4-fluoro-
4-Fluorobiphenyl
para-fluorobiphenyl
4-biphenylfluoride
Ph-C6H4-p-F
1-phenyl-4-fluorobenzene
4-Fuorobiphenyl
EINECS 206-304-1

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
253.0±0.0 °C at 760 mmHg

[ Melting Point ]:
75-79 °C(lit.)

[ Molecular Formula ]:
C₁₂H₉F

[ Molecular Weight ]:
172.198

[ Flash Point ]:
95.8±5.9 °C

[ Exact Mass ]:
172.068832

[ LogP ]:
3.91

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.553

[ Water Solubility ]:
INSOLUBLE

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DV5291200

CHEMICAL NAME :: Biphenyl, 4-fluoro-

CAS REGISTRY NUMBER :: 324-74-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H9-F

MOLECULAR WEIGHT :: 172.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 281,151,1992

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DV5291200

[ HS Code ]:
2903999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Bromobenzene
4-Fluorobenzeneboronic acid
Iodobenzene
(4-Fluorophenyl)hydrazine
benzene
1-Bromo-4-fluorobenzene
Phenylboronic acid
Chlorobenzene
4-Fluoroiodobenzene
4-Biphenylyl Trifluoromethanesulfonate

DownStream

4-Bromo-4'-fluorobiphenyl
2-fluoro-5-phenylbenzoic acid
para-Terphenyl
4'-FLUORO-[1,1'-BIPHENYL]-4-CARBONITRILE
4'-Fluoro[1,1'-biphenyl]-4-sulfonyl chloride
4'-Fluoro-4-biphenylcarboxylic acid
1-methoxy-4-(4-phenylphenyl)benzene
4-(4-phenylphenyl)morpholine
1-methyl-4-(4-phenylphenyl)benzene
1-(4'-FLUORO-BIPHENYL-4-YL)-ETHANONE

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Update on biological actions of 1alpha,25(OH)2-vitamin D3 (rapid effects) and 24R,25(OH)2-vitamin D3.

Biochem. Pharmacol. 31(10) , 1849-56, (1982)

All biologic responses to vitamin D are now known to arise as a consequence of the metabolism of this seco-steroid into its two principal biologically active metabolites 1alpha,25(OH)(2)-vitamin D(3) ...

Metabolism of 4-fluoroaniline and 4-fluorobiphenyl in the earthworm Eisenia veneta characterized by high-resolution NMR spectroscopy with directly coupled HPLC-NMR and HPLC-MS.

Xenobiotica 32(6) , 479-90, (2002)

1. Little is known about metabolism of xenobiotics by earthworms, despite their importance in soil ecotoxicity testing. Normal earthworms and earthworms treated with antibiotics to ensure inhibition o...

Biotransformation of fluorobiphenyl by Cunninghamella elegans.

Appl. Microbiol. Biotechnol. 86(1) , 345-51, (2010)

The fungus Cunninghamella elegans is a useful model of human catabolism of xenobiotics. In this paper, the biotransformation of fluorinated biphenyls by C. elegans was investigated by analysis of the ...