Isofebrifugine

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Names

[ CAS No. ]:
32434-44-9

[ Name ]:
Isofebrifugine

[Synonym ]:
(+)-inthomycin A
Phthoxazolin A
4,6,8-Decatrienamide,3-hydroxy-2,2,4-trimethyl-10-(5-oxazolyl)-,(R-(Z,Z,E))
Phthoxazolin
(R-(Z,Z,E))-3-Hydroxy-2,2,4-trimethyl-10-(5-oxazolyl)-4,6,8-decatrienamide

Chemical & Physical Properties

[ Density]:
1.48±0.1 g/cm3 (20 ºC 760 Torr)

[ Boiling Point ]:
519.8±58.0 °C(Predicted)

[ Melting Point ]:
138-139 ºC

[ Molecular Formula ]:
C16H19N3O3

[ Molecular Weight ]:
301.34000

[ Exact Mass ]:
301.14300

[ PSA ]:
76.38000

[ LogP ]:
0.95480

[ Water Solubility ]:
Very slightly soluble (0.28 g/L) (25 ºC)

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • benzyl (3aS,7aS)-2-hydroxy-2-[(4-oxo-3(4H)-quinazolinyl)methyl]hexahydrofuro[3,2-b]pyridine-4(2H)-carboxylate
  • (2R,3S)-3-benzyloxy-2-methoxy-3,6-dihydro-2H-pyran
  • 2,3-cis-3-benzyloxy-1-benzyloxycarbonyl-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)propyl]piperidin
  • Benzyl 2-allyl-3-oxo-1-piperidinecarboxylate
  • benzyl (2S,3S)-2-allyl-3-hydroxypiperidine-1-carboxylate
  • benzyl (3aS,7aS)-2-(bromomethyl)hexahydrofuro[3,2-b]pyridine-4(2H)-carboxylate
  • (3AS,7AS)-BENZYL 2-(BROMOMETHYL)-2-METHOXYHEXAHYDROFURO[3,2-B]PYRIDINE-4(2H)-CARBOXYLATE
  • (2S,3S)-2-[2-oxo-3-(4-oxo-4H-quinazolin-3-yl)propyl]-3-methoxymethoxypiperidine-1-carboxylic acid tert-butyl ester
  • cis-(3S)-3-benzyloxy-2-benzyloxycarbonylaminotetrahydropyran
  • 4-Quinazolinone

DownStream

  • Febrifugine