2(1H)-Pyrimidinone,4-amino-1-(5-chloro-5-deoxy-b-D-arabinofuranosyl)-

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Names

[ CAS No. ]:
32659-31-7

[ Name ]:
2(1H)-Pyrimidinone,4-amino-1-(5-chloro-5-deoxy-b-D-arabinofuranosyl)-

[Synonym ]:
5'-Chloroarabinosylcytosine
5'-chloro-5'-deoxyarabinosylcytosine

Chemical & Physical Properties

[ Density]:
1.86g/cm3

[ Boiling Point ]:
521.7ºC at 760mmHg

[ Molecular Formula ]:
C9H12ClN3O4

[ Molecular Weight ]:
261.66200

[ Flash Point ]:
269.3ºC

[ Exact Mass ]:
261.05200

[ PSA ]:
110.60000

[ Index of Refraction ]:
1.735

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UW7352000
CHEMICAL NAME :
2(1H)-Pyrimidinone, 4-amino-1-(5-chloro-5-deoxy-beta-D-arabinofuranosyl)-
CAS REGISTRY NUMBER :
32659-31-7
LAST UPDATED :
198706
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C9-H12-Cl-N3-O4
MOLECULAR WEIGHT :
261.69

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - mouse Leukocyte
DOSE/DURATION :
4400 nmol/L
REFERENCE :
CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-ol,2-(chloromethyl)-2,3,3a,9a-tetrahydro-6-imino-, hydrochloride (1:1),(2S,3S,3aS,9aR)-
  • 5'-chloro-5'-deoxy-2',3'-O-sulphinylcytidine hydrochloride
  • 5'-CHLORO-5'-DEOXYCYTIDINE

DownStream

  • 4-amino-1-(7-hydroxy-3,6-dioxabicyclo[2.2.1]hept-2-yl)pyrimidin-2-one

Related Compounds

  • 4-{[1-(5-Fluoro-2-methoxybenzenesulfonyl)piperidin-3-yl]methoxy}-2-methylpyridine
  • N-{2-[5-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl]ethyl}-3-(phenylsulfanyl)propanamide
  • 4-{[1-(4-Ethoxy-3-fluorobenzenesulfonyl)azetidin-3-yl]oxy}-2-methylpyridine
  • 3-Chloro-4-{[1-(2-chlorobenzenesulfonyl)piperidin-4-yl]methoxy}pyridine
  • 1-methyl-N-{2-[5-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl]ethyl}-2-(propan-2-yl)-1H-imidazole-4-sulfonamide
  • 4-{[1-(2-Methoxy-5-methylbenzenesulfonyl)piperidin-4-yl]methoxy}-3-methylpyridine
  • 4-{[1-(Isoquinoline-1-carbonyl)azetidin-3-yl]oxy}pyridine-2-carboxamide
  • 3-Chloro-4-{[1-(2,3-dihydro-1-benzofuran-5-sulfonyl)piperidin-4-yl]methoxy}pyridine
  • 4-{[1-(Dimethylsulfamoyl)azetidin-3-yl]oxy}pyridine-2-carboxamide
  • 3-{2-[5-(1-methyl-1H-pyrazol-4-yl)thiophen-2-yl]ethyl}-1-(2-methylphenyl)urea
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