(2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine

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Names

[ CAS No. ]:
327623-37-0

[ Name ]:
(2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)Morpholine

[Synonym ]:
(2R,3S)-2-{(1R)-1-[3,5-bis-trifluoromethylphenyl]ethoxy}-3-(4-fluorophenyl)morpholine
(2S,3R)-2-[(1S)-1-(3,5-bis-trifluoro-methylphenyl)ethoxy]-3-(4-fluorophenyl)morpholine
QC-634
(2S,3R)-2-((S)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholine
2s,3r------s
Aprepitant Impurity 10

Chemical & Physical Properties

[ Molecular Formula ]:
C20H18F7NO2

[ Molecular Weight ]:
437.35100

[ Exact Mass ]:
437.12300

[ PSA ]:
30.49000

[ LogP ]:
5.95690

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (2S,3R)-3-(4-fluorophenyl)-4-((R)-1-phenylethyl)morpholin-2-yl 3,5-bis(trifluoromethyl)benzoate
  • 4'-Fluoroacetophenone
  • 4-fluorophenylglyoxal hydrate

DownStream

  • Ent-Aprepitant

Related Compounds

  • 1-(2-Methoxyethyl)-4-prop-2-enoyl-1,4-diazepan-2-one
  • N-{4H,6H,7H-thiopyrano[4,3-d][1,3]thiazol-2-yl}prop-2-enamide
  • 1-Spiro[1,3-dihydroindene-2,3'-pyrrolidine]-1'-ylprop-2-en-1-one
  • N-(1-Methoxyisoquinolin-6-yl)prop-2-enamide
  • N-[(1,3-Dimethylindol-2-yl)methyl]prop-2-enamide
  • 1-(4-Cyclopropyl-2,3-dihydroquinoxalin-1-yl)prop-2-en-1-one
  • 1-Spiro[1H-2-benzofuran-3,3'-pyrrolidine]-1'-ylprop-2-en-1-one
  • 1-[3-Phenyl-3-(propan-2-yl)azetidin-1-yl]prop-2-en-1-one
  • 1-(4-Methyl-4-phenylpiperidin-1-yl)prop-2-en-1-one
  • N-[[2-(Trifluoromethyl)pyridin-4-yl]methyl]prop-2-enamide