H-D-Leu-OH

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Names

[ CAS No. ]:
328-38-1

[ Name ]:
H-D-Leu-OH

[Synonym ]:
leucine
D-Leucine
MFCD00063088
(R)-2-Amino-4-methylpentanoic acid
(2R)-2-amino-4-methylpentanoic acid
ent-1
H-Leu-OH
D-Homo-valine
D-2-Amino-4-methylvaleric acid
H-D-Leu-OH
(R)-2-Amino-4-methyl-pentanoic acid
Leucine, D-
EINECS 206-327-7
D-2-Amino-4-methylpentanoicacid

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
225.8±23.0 °C at 760 mmHg

[ Melting Point ]:
> 300ºC

[ Molecular Formula ]:
C₆H₁₃NO₂

[ Molecular Weight ]:
131.173

[ Flash Point ]:
90.3±22.6 °C

[ Exact Mass ]:
131.094635

[ PSA ]:
63.32000

[ LogP ]:
0.73

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.463

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OH2840000

CHEMICAL NAME :: Leucine, D-

CAS REGISTRY NUMBER :: 328-38-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C6-H13-N-O2

MOLECULAR WEIGHT :: 131.20

WISWESSER LINE NOTATION :: QVYZ1Y1&1 -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6429 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
22-24/25-36-26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
OH2840000

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

D-α-Hydrazino-isocapronsaeure
(R)-benzyl 4-methyl-2-((4S,5R)-2-oxo-4,5-diphenyloxazolidin-3-yl)pent-4-enoate
2-Amino-4-methylpentanoic acid
(R)-2-amino-N-((1S,2S)-1-hydroxy-1-phenylpropan-2-yl)-N,4-dimethylpentanamide
(S)-2-(Benzylamino)-4-methylpentanoic acid
(3(2R),4S)-3-(2-azido-4-methyl-1-oxopentyl)-4-(phenylmethyl)-2-oxazolidinone

DownStream

tert-Butyl (R)-2-hydroxy-4-methylpentanoate
Ketoleucine
D(-)-Glutamic acid
S-2--Bromo-4-methylvaleric acid
2-Amino-4-methylpentanoic acid
Ac-D-Leu-OH
4-Nitrophenol
N-Cbz-D-Leucine
glycyl-d-leucine
Methyl D-leucinate hydrochloride (1:1)

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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