4-Trifluoromethylsalicylic acid

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Names

[ CAS No. ]:
328-90-5

[ Name ]:
4-Trifluoromethylsalicylic acid

[Synonym ]:
Benzoic acid, 2-hydroxy-4-(trifluoromethyl)-
QVR BQ DXFFF
2-Hydroxy-4-(trifluoromethyl)benzoic acid
MFCD01529657
4-Trifluoromethylsalicylic acid
4-Trifluoromethyl Salicylic Acid
2-hydroxy-4-trifluoromethyl benzoic acid
Triflusal impurity B
4-(TrifluoroMethyl)salicylic Acid
4-Tfmsa

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
286.4±40.0 °C at 760 mmHg

[ Melting Point ]:
178ºC

[ Molecular Formula ]:
C8H5F3O3

[ Molecular Weight ]:
206.119

[ Flash Point ]:
127.0±27.3 °C

[ Exact Mass ]:
206.019073

[ PSA ]:
57.53000

[ LogP ]:
4.16

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.510

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36/37/39

[ HS Code ]:
2918290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-(Trifluoromethyl)benzoic acid
  • 2-methoxymethoxy-4-(trifluoromethyl)benzene
  • Carbon dioxide
  • 3-(Trifluoromethyl)phenol
  • 4-Trifluoromethylphenol
  • 1-(Methoxymethoxy)-4-(trifluoromethyl)benzene
  • 1-MethoxyMethoxy-3-trifluoromethyl-benzene
  • Triflusal
  • 2,5-Bis(trifluoromethyl)phenol
  • 2,5-Bis(trifluoromethyl)aniline

DownStream

  • Triflusal
  • 2-METHOXY-4-TRIFLUOROMETHYL METHYLBENZOATE
  • 2-Hydroxy-4-(methoxycarbonyl)benzoic acid
  • 2-Hydroxyterephthalic acid
  • Benzoic acid,2-hydroxy-4-(trifluoromethyl)-, methyl ester
  • Benzamide,2-hydroxy-N-phenyl-4-(trifluoromethyl)-
  • Benzamide,2-hydroxy-4-(trifluoromethyl)-

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.

Eur. J. Pharm. Sci. 31(3-4) , 211-20, (2007)

In this research, the effects of micellar systems on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) were found to be dependant upon the surfactant charge within the mi...

A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.

Expert Opin. Drug Metab. Toxicol. 7(12) , 1471-9, (2011)

An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compa...

Salicylates increase insulin secretion in healthy obese subjects.

J. Clin. Endocrinol. Metab. 93(7) , 2523-30, (2008)

Conflicting results on the effects of salicylates on glucose tolerance in subjects with normal glucose tolerance or type 2 diabetes have been reported.The objective of the study was to investigate the...


More Articles

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