Pivaloyl chloride

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Names

[ CAS No. ]:
3282-30-2

[ Name ]:
Pivaloyl chloride

[Synonym ]:
PIVALYL CHLORIDE
2,2,2-trimethylacetyl chloride
Pivaloylchlorid
2,2-dimethylpropionic acid chloride
Trimethylacetyl
2,2-dimethyl-propionyl chloride
PVCL
pivaloyl
MFCD00000709
2,2-Dimethylpropanoyl chloride
2,2-Dimethylpropionyl Chloride
Pivaloyl chlorode
Pivalpyl chloride
EINECS 221-921-6
Pivaloyl chloride
Pivalolyl chloride
1-chloro-2,2-dimethylpropionaldehyde
2,2-Dimethylpropanoic acid chloride
Propanoyl chloride, 2,2-dimethyl-
Trimethylacetyl chloride
Pyvaloylchloride

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
107.2±8.0 °C at 760 mmHg

[ Melting Point ]:
-56 °C

[ Molecular Formula ]:
C5H9ClO

[ Molecular Weight ]:
120.577

[ Flash Point ]:
8.9±0.0 °C

[ Exact Mass ]:
120.034195

[ PSA ]:
17.07000

[ LogP ]:
1.68

[ Vapour density ]:
>1 (vs air)

[ Vapour Pressure ]:
27.4±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.417

[ Water Solubility ]:
Hydrolysis

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302-H314-H330

[ Supplemental HS ]:
Reacts violently with water.

[ Precautionary Statements ]:
P210-P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P403 + P233

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
F:Flammable

[ Risk Phrases ]:
R11;R22;R23;R34

[ Safety Phrases ]:
S16-S26-S36/37/39-S45-S38-S28A

[ RIDADR ]:
UN 2438 6.1/PG 1

[ WGK Germany ]:
1

[ Packaging Group ]:
I

[ Hazard Class ]:
6.1

[ HS Code ]:
29159080

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methyl tert-butyl ether
  • 4-Chloroaniline
  • Pivalic acid
  • tert-butyl chloride
  • Trifluoromethanesulfonic acid
  • carbon monoxide
  • Isobutylene
  • Thionyl chloride
  • 3,3-dichloro-1,2-diisopropylcycloprop-1-ene
  • Benzoyl chloride

DownStream

  • (7-methyl-2,3-diphenylindolizin-1-yl) 2,2-dimethylpropanoate
  • 2-[(2,2-DIMETHYLPROPANOYL)AMINO]BENZOIC ACID
  • 6-pivalamidopyridine-3-boronic acid pinacol ester
  • 2,2-dimethyl-N-(2-oxo-3-piperidyl)propanamide
  • 2-(2,2-dimethylpropanoyloxy)-2-methylpropanoic acid
  • N-(4-aMinophenyl)-2,2-diMethylpropanaMide
  • 2,2-dimethyl-1-(1-methylpyrrol-3-yl)propan-1-one
  • 1,1'-(1-methyl-1H-pyrrole-3,4-diyl)bis(2,2-dimethyl-1-propanone)
  • 1,1'-(1''-methyl-1''H-pyrrol-2'',4''-diyl)bis(2,2-dimethylpropan-1-one)
  • 2,2-dimethyl-1-(1-methylpyrrol-2-yl)propan-1-one

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3.

Bioorg. Med. Chem. 23(5) , 1123-34, (2015)

Proteinase 3 (Pr3), and human neutrophil elastase (HNE) are two major neutrophilic serine proteases (NsPs) expressed in neutrophil azurophil granules. Emerging data suggest that excessive release of p...

Selective pivaloylation of 2-acetamido-2-deoxy sugars.

Carbohydr. Res. 182(2) , 197-205, (1988)

Selective pivaloylation of 2-acetamido-2-deoxy-D-glucose, its methyl alpha- and beta-glycosides, and the methyl alpha-glycoside of N-acetyl-D-muramic acid under various conditions has been studied. Th...

Selective pivaloylation and diphenylacetylation of cyclomalto-oligosaccharides.

Carbohydr. Res. 262(2) , 271-82, (1994)

Regioselective acylation of cyclomalto-oligosaccharides was achieved using pivaloyl and diphenylacetyl chlorides. The reaction of cyclomaltohexaose (1) with pivaloyl chloride gave the hexakis(2,6-di-O...


More Articles

Related Compounds

  • Pivaloyl chloride-d9
  • Chloropivaloyl chloride
  • bromo-pivaloyl chloride
  • bromo-pivaloyl chloride
  • pivaloyl-proline N-methylamide
  • pivaloyl-prolyl-δ-aminovaleric acid methyl ester monohydrate
  • 2-Cyclopropyl-5-(3-nitrophenyl)-1H-imidazole
  • (1-(Hydrazinylmethyl)cyclopropyl)methanethiol
  • 3-Chloro-5-cyclopropylisoquinoline
  • 2-Bromo-4-fluoro-6-iodobenzonitrile
  • 1-[4-chloro-2-(methylthio)-5-pyrimidinyl]Cyclopropanecarboxylic acid, ethyl ester
  • 4-(2-Chloro-3-pyridinyl)-6-(methylthio)pyrimidine
  • 1-(1-Chloroisoquinolin-8-yl)ethan-1-one
  • 8-Bromo-1-vinylisoquinoline
  • 6-Ethynyl-2-methylisoquinolin-1(2H)-one
  • N-(2,2-dimethoxyethyl)-3,4-dimethoxy-2,5-dimethylbenzamide
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