4-Methoxybenzohydrazide

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Names

[ CAS No. ]:
3290-99-1

[ Name ]:
4-Methoxybenzohydrazide

[Synonym ]:
Anisic hydrazide
4-Methoxybenzoylhydrazine
4-methoxybenzoyl hydrazide
p-Anisic Hydrazide
p-Anisohydrazide
EINECS 221-952-5
MFCD00017073
4-Methoxybenzoic acid hydrazide
p-Anisoylhydrazine
Benzoic acid, 4-methoxy-, hydrazide
anisohydrazide
4-methoxyphenyl-1-carbohydrazide
p-methoxy-benzoic acid hydrazide
4-Methoxybenzohydrazide
4-Methoxybenzhydrazide
P-ANISIC ACID HYDRAZIDE
Anisoylhydrazine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Melting Point ]:
136-140 °C(lit.)

[ Molecular Formula ]:
C8H10N2O2

[ Molecular Weight ]:
166.177

[ Exact Mass ]:
166.074234

[ PSA ]:
64.35000

[ LogP ]:
0.25

[ Index of Refraction ]:
1.558

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BZ4800000
CHEMICAL NAME :
p-Anisic acid, hydrazide
CAS REGISTRY NUMBER :
3290-99-1
BEILSTEIN REFERENCE NO. :
0389017
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H10-N2-O2
MOLECULAR WEIGHT :
166.20
WISWESSER LINE NOTATION :
ZMVR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
178 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00894 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 gm/kg/22W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
REFERENCE :
34ZRA9 "Proceedings of the Quadrennial Conference on Cancer, 3rd, 1965," Severi, L., ed., Perugia, Italy, Univ. of Perugia, 1966 Volume(issue)/page/year: -,869,1965

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
BZ4800000

Synthetic Route

Precursor & DownStream

Precursor

  • Methyl anisate
  • Ethyl 4-methoxybenzoate
  • p-Anisic acid
  • o-Phenylenediamine
  • p-Anisoyl chloride
  • 4-Methoxybenzaldehyde
  • 4-Hydroxybenzoic acid

DownStream

  • Methyl anisate
  • p-Anisic acid
  • 3-(4-methoxyphenyl)-4-(4-methylphenyl)-5-(phenoxymethyl)-1,2,4-triazol e
  • DY131
  • ETHYL 2-[(4-METHOXYBENZOYL)AMINO]ACETATE
  • Ethyl 4-methoxybenzoate
  • N-(cyclohexylideneamino)-4-methoxybenzamide
  • 4-(5-METHYL-1,3,4-OXADIAZOL-2-YL)PHENOL
  • 2-(4-methoxyphenyl)-1,3,4-oxadiazole
  • 4-Methoxybenzamide

Articles

Metallodynamers: neutral double-dynamic metallosupramolecular polymers.

Chem. Asian J. 3(8-9) , 1324-35, (2008)

Nine neutral dynamic metallosupramolecular polymers (metallodynamers) based on acyl hydrazone derived metal coordination centers (Co(2+), Ni(2+), Zn(2+), and Cd(2+)) were generated through self-assemb...


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Related Compounds

  • 3-Iodo-4-methoxybenzohydrazide
  • 3-Bromo-4-methoxybenzohydrazide
  • 2-chloro-4-methoxybenzohydrazide
  • 3-Chloro-4-Methoxybenzohydrazide
  • 2-Hydroxy-4-methoxybenzohydrazide
  • 3,5-Diiodo-4-methoxybenzohydrazide
  • (4E)-N-(1,3-benzodioxol-5-ylmethyl)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enamide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 2-(4-fluoro-1-methyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine