COLCHICINE, O(sup 1)-DEMETHYL-, ACETATE

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Names

[ CAS No. ]:
3306-60-3

[ Name ]:
COLCHICINE, O(sup 1)-DEMETHYL-, ACETATE

[Synonym ]:
1-O-acetyl-1-O-demethyl-colchicine
1-Demethyl-1-acetylcolchicine

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
729.6ºC at 760 mmHg

[ Molecular Formula ]:
C23H25NO7

[ Molecular Weight ]:
427.44700

[ Flash Point ]:
395ºC

[ Exact Mass ]:
427.16300

[ PSA ]:
100.16000

[ LogP ]:
3.17920

[ Index of Refraction ]:
1.587

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0881000
CHEMICAL NAME :
Colchicine, O(sup 1)-demethyl-, acetate
CAS REGISTRY NUMBER :
3306-60-3
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H25-N-O7
MOLECULAR WEIGHT :
427.49
WISWESSER LINE NOTATION :
L B677 MV&T&J COV1 DO1 EO1 JMV1 OO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
88 mg/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Colchicine
  • Acetyl chloride

DownStream

  • 1-Demethylcolchicine

Related Compounds

  • Thiocolchicine analog
  • 3-demethylthiocolchicine
  • azane,cobalt(2+),2-oxopentanedioate
  • 2-hydroxypropanoate,vanadium,dichloride
  • Lappaconine
  • cobalt(2+),hydron,2-oxopentanedioate,dihydrate
  • 2-(Bromomethyl)naphthalene-6-carboxaldehyde
  • 2-(Chloromethyl)-3-(difluoromethyl)pyridine-6-acetonitrile
  • 2-(Bromomethyl)-4-(difluoromethyl)pyridine-3-carboxylic acid
  • 2-(Bromomethyl)-5-fluorophenylhydrazine
  • 4-Chloro-3-cyano-5-mercaptobenzene-1-sulfonyl chloride
  • 2-(Bromomethyl)-4-cyano-6-(difluoromethyl)pyridine-3-acetonitrile
  • 2-(Chloromethyl)-3-(difluoromethyl)-6-fluoropyridine-5-carboxaldehyde
  • 2-(Chloromethyl)-3-(difluoromethyl)-4-methoxy-5-(trifluoromethoxy)pyridine
  • 2-(Chloromethyl)-3-(difluoromethyl)-6-methylpyridine-5-acetic acid
  • 2-(Bromomethyl)-5-cyano-4-(difluoromethyl)-3-nitropyridine
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