ethane-1,2-diaminium dichloride

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Names

[ CAS No. ]:
333-18-6

[ Name ]:
ethane-1,2-diaminium dichloride

[Synonym ]:
1,2-Ethanediamine, hydrochloride (1:2)
Ethylene diamine dihydrochloride
Ethylenediammonium dichloride
EINECS 206-369-6
1,2-Ethanediamine dihydrochloride
ethane-1,2-diamine,dihydrochloride
Ethane-1,2-diamine dihydrochloride
Ethylenediamine dihydrochloride
Ethylenediammonium chloride
1,2-ethyldiamine dihydrochloride
MFCD00012524
dihydrochloride salt of 1,2-diaminoethane
Chlor-ethamine
ethylenediammonium hydrochloride
1,2-Diaminoethane dihydrochloride
Dimethylenediamine diydrochloride
ethane-1,2-diaminium dichloride

Chemical & Physical Properties

[ Density]:
1.159g/cm3

[ Boiling Point ]:
472.9ºC at 760mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₂H₁₀Cl₂N₂

[ Molecular Weight ]:
133.020

[ Flash Point ]:
239.8ºC

[ Exact Mass ]:
132.022110

[ PSA ]:
52.04000

[ LogP ]:
1.90840

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
300 g/L (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KV3850000

CHEMICAL NAME :: Ethylenediamine, dihydrochloride

CAS REGISTRY NUMBER :: 333-18-6

LAST UPDATED :: 199806

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C2-H8-N2.2Cl-H

MOLECULAR WEIGHT :: 133.04

WISWESSER LINE NOTATION :: Z2Z &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EMSUA8 Experimental Medicine and Surgery. (Brooklyn, NY) V.1-29, 1943-71. Suspended. Volume(issue)/page/year: 4,223,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1620 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 3,512,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1064 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,1117,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 940 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,649,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >6400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 3,512,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 17290 ug/kg/7D-C

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 3,512,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 783 mg/kg/91D-C

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 3,512,1983

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 256 gm/kg/2Y-C

TOXIC EFFECTS :: Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,53,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 255 gm/kg/2Y-C

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534551

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18900 ug/kg/7D-C

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 3,512,1983 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,165,1984

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 10 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,687,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80412 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80412 No. of Facilities: 426 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 5930 (estimated) No. of Female Employees: 2366 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H317-H319-H334-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38;R42/43

[ Safety Phrases ]:
S22-S26-S36/37-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
KV3850000

[ HS Code ]:
29212100

Precursor & DownStream

Precursor

2-Imidazolidinone
Hydrochloric acid
Boron, [m-(1,2-ethanediamine-kN:kN')]hexahydrodi-
Water
1,2-Ethanediamine
Acrylyl chloride
Methanol
ethylenediammonium galactarate
SUCCINYL CHLORIDE
benzene

DownStream

1H-Imidazole,4,5-dihydro-2-undecyl-
Urea,N,N''-1,2-ethanediylbis-
dibenzo(f,h)quinoxaline
tert-Butyl-(2-aminoethyl)carbamathydrochlorid
N-Nitroimidazolidin-2-imine
N-(2-Aminoethyl)benzamide
Benzamide,N,N'-1,2-ethanediylbis-
1H-Imidazole,4,5-dihydro-2-pentadecyl-
3-Chloro-1,2,5-thiadiazole
3,4-Dichloro-1,2,5-thiadiazole

Customs

[ HS Code ]: 2921219000

[ Summary ]:
2921219000 ethylenediamine and its salts。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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N,N,N'-trimethylethane-1,2-diaminium dichloride
n,n,n',n'-tetrakis(2-chloropropyl)ethane-1,2-diaminium dichloride
N,N-diethyl-N'-(1-nitroacridin-9-yl)ethane-1,2-diaminium dichloride
n,n-dibenzyl-n',n'-bis(2-chloroethyl)ethane-1,2-diaminium dichloride
N,N-bis(2-chloroethyl)-N',N'-dicyclohexylethane-1,2-diaminium dichloride
n,n-bis(2-chloroethyl)-n'-cyclohexyl-n'-methylethane-1,2-diaminium dichloride
N-(2-Amino-4-bromophenyl)-Na(2)-(3-fluorophenyl)urea
2-Neopentyl-3H-imidazo[4,5-b]pyridine
benzyl (3R,4R)-3-amino-4-fluoropyrrolidine-1-carboxylate
I+/--[[2-(3-Thienyl)acetyl]amino]cyclohexaneacetic acid
1-(2,6-Dimethylphenyl)-3-phenyl-1H-pyrazole
4-(4-Fluorophenyl)-2-methylthiazol-5-amine
4-(2-Bromophenyl)thiazol-5-amine
1-Allyl-4-(2-fluorophenyl)-2-methyl-1H-imidazol-5-amine
4-(2-Fluorophenyl)-2-methyl-1-(prop-2-yn-1-yl)-1H-imidazol-5-amine
Methyl[(1-methylcyclopropyl)methyl]amine

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