Diazomethane
Suppliers
Names
[ CAS No. ]:
334-88-3
[ Name ]:
Diazomethane
[Synonym ]:
Methane,diazo
Acomethylene
Azimethylene
Diazirine
Diazonium methylide
EINECS 206-382-7
Chemical & Physical Properties
[ Melting Point ]:
-145ºC
[ Molecular Formula ]:
CH2N2
[ Molecular Weight ]:
42.04000
[ Exact Mass ]:
42.02180
[ PSA ]:
37.39000
[ Index of Refraction ]:
1.684
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PA7000000
- CHEMICAL NAME :
- Methane, diazo-
- CAS REGISTRY NUMBER :
- 334-88-3
- BEILSTEIN REFERENCE NO. :
- 0102415
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 34
- MOLECULAR FORMULA :
- C-H2-N2
- MOLECULAR WEIGHT :
- 42.05
- WISWESSER LINE NOTATION :
- NNU1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 175 ppm/10M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 272 mg/m3/26W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 272 mg/m3/26W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 48 gm/kg/52W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Mold - Neurospora crassa
- REFERENCE :
- HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947- Volume(issue)/page/year: 35,521,1949 *** REVIEWS *** ACGIH TLV-Suspected human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.34 mg/m3 (0.2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,223,1974 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 7,223,1974 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.2 ppm (0.4 mg/m3) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,15,1973 OSHA PEL (Gen Indu):8H TWA 0.2 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.2 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.2 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.2 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.2 ppm (0.4 mg/m3);Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 mg/m3;STEL 0.2 mg/m3 JAN 1993 OEL-FINLAND:TWA 0.2 ppm (0.4 mg/m3) JAN 1993 OEL-FRANCE:TWA 0.2 ppm (0.4 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.2 ppm (0.3 mg/m3);STEL 0.6 ppm (1.0 mg/m3);Carcinogen JAN 1993 OEL-HUNGARY;Carcinogen JAN 1993 OEL-INDIA:STEL 0.4 mg/m3;Skin JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 ppm (0.4 mg/m3) JAN 1993 OEL-RUSSIA:TWA 0.2 ppm (0.4 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.2 ppm (0.35 mg/m3);Carcinogen JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 ppm (0.4 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO DIAZOMETHANE-air:10H TWA 0.2 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 23370 No. of Facilities: 18 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 234 (estimated)
Safety Information
[ Hazard Codes ]:
Xi,Xn
[ Risk Phrases ]:
45
[ Safety Phrases ]:
53-45
[ RIDADR ]:
1953
[ WGK Germany ]:
3
[ Hazard Class ]:
2.3