N-Phthalyl-DL-glutamic Anhydride

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Names

[ CAS No. ]:
3343-28-0

[ Name ]:
N-Phthalyl-DL-glutamic Anhydride

[Synonym ]:
2-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-1H-isoindole-1,3(2H)-dione
N-Phthalyl-glutaminsaeureanhydrid
1H-Isoindole-1,3(2H)-dione, 2-(tetrahydro-2,6-dioxo-2H-pyran-3-yl)-
N-phthaloylglutamic acid anhydride
N-PHTHALOYL-L-GLUTAMIC ANHYDRIDE
EINECS 222-088-1
N-Phthalyl-DL-glutamic Anhydride
N-Phthaloyl-DL-glutaMic Anhydride
MFCD00005886
2-Phthalimidoglutaric Anhydride

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
484.8±38.0 °C at 760 mmHg

[ Melting Point ]:
197-201ºC(lit.)

[ Molecular Formula ]:
C13H9NO5

[ Molecular Weight ]:
259.214

[ Flash Point ]:
247.0±26.8 °C

[ Exact Mass ]:
259.048065

[ PSA ]:
80.75000

[ LogP ]:
0.29

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.647

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA3900000
CHEMICAL NAME :
Glutaric anhydride, 2-phthalimido-
CAS REGISTRY NUMBER :
3343-28-0
BEILSTEIN REFERENCE NO. :
0090174
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C13-H9-N-O5
MOLECULAR WEIGHT :
259.23
WISWESSER LINE NOTATION :
T56 BVNVJ C- DT6VOVTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
900 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 3,987,1964

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302 + H312 + H332-H315-H319-H335-H351

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-36/37/38-40

[ Safety Phrases ]:
S23;S26;S45;S36/S37/S39

[ RIDADR ]:
]

[ RTECS ]:
MA3900000

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Pentanedioic acid,2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
  • Phthalic anhydride
  • L-glutamic acid
  • Ethanoic anhydride

DownStream

  • Thalidomide
  • Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).
  • 5-Amino-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoic acid
  • N-METHYL-2-PHTHALIMIDOGLUTARIMIDE
  • 2-(2,6-dioxo-1-propylpiperidin-3-yl)isoindole-1,3-dione
  • 2-(2,6-dioxo-1-pentylpiperidin-3-yl)isoindole-1,3-dione
  • Pentanedioic acid,2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
  • 2-(2,6-dioxo-1-phenylpiperidin-3-yl)isoindole-1,3-dione

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • n-phthalyl-dl-glutamic anhydride
  • 3,4-dimethyl-N-benzoyl-DL-glutamic anhydride
  • phthaloyl-l-glutamic anhydride
  • 2-phthalimidoglutaric acid
  • 4-benzyl-6-(phenoxathiin-2-yl)-3-(N-phthalyl-DL-alanyl)amino-pyrimidine
  • 4-benzyl-6-(phenoxathiin-2-yl)-3-(N-phthalyl-DL-alanyl)mercapto-pyrimidine