2H-Isoindole-2-aceticacid, a-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-,(aS)-

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Names

[ Name ]:
2H-Isoindole-2-aceticacid, a-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-,(aS)-

[Synonym ]:
PHTHALYL-L-GLUTAMINE
Phthalyl-L-glutamin
(S)-4-Carbamoyl-2-(1,3-dioxo-1,3-di; hydro-isoindol-2-yl)-butyric acid
N2,N2-Phthaloyl-L-glutamin
N-phthaloyl-L-glutamine
PHT-GLN-OH
N-alpha-Phthalyl-L-Glutamine
N2,N2-phthaloyl-L-glutamine
(2S)-5-Amino-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoic acid
2H-Isoindole-2-acetic acid, α-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-, (αS)-
MFCD00190993
PHTHALOYL-L-GLUTAMINE

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
599.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₂N₂O₅

[ Molecular Weight ]:
276.245

[ Flash Point ]:
316.3±28.7 °C

[ Exact Mass ]:
276.074615

[ PSA ]:
117.77000

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.639

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD2430000

CHEMICAL NAME :: Norvaline, 5-(1,3-dioxo-2-isoindolinyl)-5-oxo-, DL-

CAS REGISTRY NUMBER :: 3343-29-1

LAST UPDATED :: 199712

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H12-N2-O5

MOLECULAR WEIGHT :: 276.27

WISWESSER LINE NOTATION :: T56 BVNVJ CV2YZVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 50 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep. Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA. Volume(issue)/page/year: 26B,857,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: female 9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep. Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA. Volume(issue)/page/year: 26B,857,1971

Safety Information

[ HS Code ]:
2925190090

Precursor & DownStream

Precursor

Phthalic anhydride
L-Glutamine
N-carbethoxyphthalimide
phthaloyl-l-glutamic anhydride

DownStream

Thalidomide
L(-)-Tryptophan
(S)-Thalidomide

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

Naphthalen-1-yl(7-(o-tolyl)-1,4-thiazepan-4-yl)methanone
(2-Chloro-4-fluorophenyl)(7-(o-tolyl)-1,4-thiazepan-4-yl)methanone
(2-((Difluoromethyl)thio)phenyl)(7-(o-tolyl)-1,4-thiazepan-4-yl)methanone
1-(7-(o-Tolyl)-1,4-thiazepan-4-yl)-2-(4-(trifluoromethyl)phenyl)ethanone
2-((1H-indol-3-yl)thio)-1-(7-(o-tolyl)-1,4-thiazepan-4-yl)ethanone
2-(Benzo[d]thiazol-2-ylthio)-1-(7-(2,5-difluorophenyl)-1,4-thiazepan-4-yl)ethanone
(2,5-Dichlorophenyl)(7-(2,5-difluorophenyl)-1,4-thiazepan-4-yl)methanone
(7-(2,5-Difluorophenyl)-1,4-thiazepan-4-yl)(2-(trifluoromethyl)phenyl)methanone
(7-(2,5-Difluorophenyl)-1,4-thiazepan-4-yl)(1-(thiophen-2-yl)cyclopentyl)methanone
(7-(2,5-Difluorophenyl)-1,4-thiazepan-4-yl)(4-(trifluoromethoxy)phenyl)methanone

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