2H-Isoindole-2-aceticacid, a-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-,(aS)-

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Names

[ CAS No. ]:
3343-29-1

[ Name ]:
2H-Isoindole-2-aceticacid, a-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-,(aS)-

[Synonym ]:
PHTHALYL-L-GLUTAMINE
Phthalyl-L-glutamin
(S)-4-Carbamoyl-2-(1,3-dioxo-1,3-di; hydro-isoindol-2-yl)-butyric acid
N2,N2-Phthaloyl-L-glutamin
N-phthaloyl-L-glutamine
PHT-GLN-OH
N-alpha-Phthalyl-L-Glutamine
N2,N2-phthaloyl-L-glutamine
(2S)-5-Amino-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-5-oxopentanoic acid
2H-Isoindole-2-acetic acid, α-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-, (αS)-
MFCD00190993
PHTHALOYL-L-GLUTAMINE

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
599.3±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H12N2O5

[ Molecular Weight ]:
276.245

[ Flash Point ]:
316.3±28.7 °C

[ Exact Mass ]:
276.074615

[ PSA ]:
117.77000

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.639

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RD2430000
CHEMICAL NAME :
Norvaline, 5-(1,3-dioxo-2-isoindolinyl)-5-oxo-, DL-
CAS REGISTRY NUMBER :
3343-29-1
LAST UPDATED :
199712
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C13-H12-N2-O5
MOLECULAR WEIGHT :
276.27
WISWESSER LINE NOTATION :
T56 BVNVJ CV2YZVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
50 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep. Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA. Volume(issue)/page/year: 26B,857,1971
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie. (Tuebingen, Fed. Rep. Ger.) V.2B-27B, 1947-1972. For publisher information, see ZNCBDA. Volume(issue)/page/year: 26B,857,1971

Safety Information

[ HS Code ]:
2925190090

Precursor & DownStream

Precursor

  • Phthalic anhydride
  • L-Glutamine
  • N-carbethoxyphthalimide
  • phthaloyl-l-glutamic anhydride

DownStream

  • Thalidomide
  • L(-)-Tryptophan
  • (S)-Thalidomide

Customs

[ HS Code ]: 2925190090

[ Summary ]:
2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[2-(Tert-butoxy)ethoxy]-1-(iodomethyl)cyclohexane
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 4-Bromo-3-cyano-5-iodobenzoic acid
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 4-Pyrimidinamine, 2-(3-ethyl-1-methyl-1H-pyrazol-4-yl)-5-iodo-N-methyl-
  • Ethyl 2-[(pent-4-yn-2-yl)amino]-1,3-oxazole-4-carboxylate
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide