Ciproquazone

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Names

[ CAS No. ]:
33453-23-5

[ Name ]:
Ciproquazone

[Synonym ]:
1-Cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-chinazolinon
1-Cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-quinazolinone
1-cyclopropylmethyl-6-methoxy-4-phenyl-1H-quinazolin-2-one
Ciproquazonum [INN-Latin]
CIPROQUAZONE
SL-573
Ciproquazona
1-(Cyclopropyl-methyl)-4-phenyl-6-methoxy-1H-chinazolinon-(2)
2(1H)-Quinazolinone,1-(cyclopropylmethyl)-6-methoxy-4-phenyl
1-(Cyclopropylmethyl)-6-methoxy-4-phenyl-2(1H)-quinazolinone
Ciproquazona [INN-Spanish]

Chemical & Physical Properties

[ Density]:
1.26g/cm3

[ Boiling Point ]:
483.8ºC at 760mmHg

[ Molecular Formula ]:
C19H18N2O2

[ Molecular Weight ]:
306.35800

[ Flash Point ]:
246.4ºC

[ Exact Mass ]:
306.13700

[ PSA ]:
44.12000

[ LogP ]:
3.48210

[ Index of Refraction ]:
1.653

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VA3100333
CHEMICAL NAME :
2(1H)-Quinazolinone, 1-(cyclopropylmethyl)-6-methoxy-4-phenyl-
CAS REGISTRY NUMBER :
33453-23-5
BEILSTEIN REFERENCE NO. :
0761592
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C19-H18-N2-O2
MOLECULAR WEIGHT :
306.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg/30D-I
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - changes in testicular weight
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1991,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9100 mg/kg/13W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 13,1991,1979

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2-Dichlorobenzene
  • 1-cyclopropylmethyl-6-methoxy-4-phenyl-3,4-dihydro-1H-quinazolin-2-one

DownStream

Related Compounds

  • 4-amino-N~5~-cyclopentyl-N~3~-isopropylisothiazole-3,5-dicarboxamide
  • 4-amino-N5-[(2-fluorophenyl)methyl]-N3-(propan-2-yl)-1,2-thiazole-3,5-dicarboxamide
  • 4-amino-N5-[(5-methylfuran-2-yl)methyl]-N3-(propan-2-yl)-1,2-thiazole-3,5-dicarboxamide
  • 4-amino-N5-{[4-(methylsulfanyl)phenyl]methyl}-N3-(propan-2-yl)-1,2-thiazole-3,5-dicarboxamide
  • 4-amino-N3-(propan-2-yl)-N5-[(pyridin-4-yl)methyl]-1,2-thiazole-3,5-dicarboxamide
  • 4-amino-5-[4-(2-methoxyphenyl)piperazine-1-carbonyl]-N-(propan-2-yl)-1,2-thiazole-3-carboxamide
  • 4-amino-5-(4-cyclohexylpiperazine-1-carbonyl)-N-isopropylisothiazole-3-carboxamide
  • 4-amino-N-(propan-2-yl)-5-[4-(pyrimidin-2-yl)piperazine-1-carbonyl]-1,2-thiazole-3-carboxamide
  • 4-amino-5-[4-(3-methoxyphenyl)piperazine-1-carbonyl]-N-(propan-2-yl)-1,2-thiazole-3-carboxamide
  • N-(5-chloro-2-methylphenyl)-2-((7-methylpyrimido[4,5-d]pyrimidin-4-yl)thio)acetamide
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