Benzo[a]pyren-6-ol

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Names

[ Name ]:
Benzo[a]pyren-6-ol

[Synonym ]:
benzo<a>pyren-6-ol
benzo[def]chrysen-6-ol
6-Hydroxy-benzo[def]chrysen
6-hydroxybenzo<a>pyrene
Benzo[a]pyrenol-(6)
5-Hydroxy-3,4-benzopyrene
Benzo(a)pyrene,6-hydroxy
6-Hydroxy-benzo[a]pyren

Chemical & Physical Properties

[ Density]:
1.379g/cm3

[ Boiling Point ]:
527.2ºC at 760 mmHg

[ Molecular Formula ]:
C₂₀H₁₂O

[ Molecular Weight ]:
268.30900

[ Flash Point ]:
252.9ºC

[ Exact Mass ]:
268.08900

[ PSA ]:
20.23000

[ LogP ]:
5.44280

[ Index of Refraction ]:
1.924

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ8260000

CHEMICAL NAME :: Benzo(a)pyren-6-ol

CAS REGISTRY NUMBER :: 33953-73-0

BEILSTEIN REFERENCE NO. :: 1982121

LAST UPDATED :: 199612

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C20-H12-O

MOLECULAR WEIGHT :: 268.32

WISWESSER LINE NOTATION :: L D6 B6666 2AB TJ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4280 ug/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Blood - leukemia Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intradermal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2400 ug/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4290 ug/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 5 mg/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 36,3350,1976 *** REVIEWS *** TOXICOLOGY REVIEW ABSYB2 Alfred Benzon Symposium. (Nankodo Co. Ltd., POB 5272, Tokyo International 100-31, Japan) V.1- 1968- Volume(issue)/page/year: 10,261,1977

Safety Information

[ HS Code ]:
2906299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

6-FLUOROBENZO(a)PYRENE
Butylmagnesium Bromide
6-ACETOXY-BENZO(a)PYRENE
4-oxo-2,2a,3,4-tetrahydrophenaleno[1,9-bc]furan
2,2a,3,4-tetrahydrophenaleno[1,9-bc]furan-4-ol
3,4-dihydrophenaleno[1,9-bc]furan-4-ol
phenaleno[1,9-bc]furan
1,2-Dibromobenzene
6-nitrobenz(a)pyrene

DownStream

Benzo[a]pyrene-1,6-dione
6-ACETOXY-BENZO(a)PYRENE

Customs

[ HS Code ]: 2906299090

[ Summary ]:
2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Related Compounds

Benzo[a]pyren-6-ol
1-nitrobenzo[a]pyren-6-ol
Benzo[a]pyren-6-ol,acetate
2-benzo[b]pyren-6-ylcyclohexan-1-ol
Methylium,benzo(a)pyren-6-yl
2-amino-8-(benzo[b]pyren-6-ylmethyl)-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
2-(1H-indol-1-yl)-1-(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)ethanone
(7-Methoxybenzofuran-2-yl)(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)methanone
(2-Methylthiazol-4-yl)(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)methanone
(E)-3-(2-chlorophenyl)-1-(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)prop-2-en-1-one
2-methyl-6-(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazine-1-carbonyl)pyridazin-3(2H)-one
3-(3,5-Dimethylisoxazol-4-yl)-1-(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)propan-1-one
2-(o-Tolyloxy)-1-(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)ethanone
2-(Benzylthio)-1-(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)ethanone
2-(Naphthalen-1-yl)-1-(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)ethanone
Methyl 2-(4-(6-(trifluoromethyl)pyrimidin-4-yl)piperazine-1-carbonyl)benzoate

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