L-Hydroxyproline

Suppliers

Names

[ Name ]:
L-Hydroxyproline

[Synonym ]:
(2S,4R)-4-hydroxypyrrolidinium-2-carboxylate
Hydroxyproline
H-D-HYP-OH
Proline, 4-hydroxy-, L-
trans-4-hydroxyproline
trans-4-D-Hydroxyproline
(2S,4R)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid
TRANS-D-HYDROXYPROLINE
MFCD00065608
Trans-4-Hydroxy-D-Proline
trans-4-Hydroxy-L-proline
(2R,4S)-4-Hydroxypyrrolidine-2-Carboxylic Acid
(2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid
D-trans-Hydroxyproli
L-Proline, 4-hydroxy-, trans- (9CI)
L-Proline, 4-hydroxy-, (4R)-
(-)-(2S,4R)-4-HYDROXYPROLINE
(2S,4R)-4-hydroxyproline
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
TRANS-D-4-HYDROXYPROLINE
(trans)-4-Hydroxy-L-proline
(2S,4R)-trans-4-hydroxyproline
(4R)-4-Hydroxy-L-proline
L-Proline, 4-hydroxy-, trans-
D-HYDROXYPYROLINE
D-HYDROXYPROLINE
trans-D-Hyp

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
355.2±42.0 °C at 760 mmHg

[ Melting Point ]:
260°C

[ Molecular Formula ]:
C₅H₉NO₃

[ Molecular Weight ]:
131.130

[ Flash Point ]:
168.6±27.9 °C

[ Exact Mass ]:
131.058243

[ PSA ]:
69.56000

[ LogP ]:
-1.84

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.540

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H315-H319-H334-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S24/25-S36/37-S26

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

tans-4-Hydroxy-D-proline methyl ester hydrochloride
Pyrrole 2-carboxylate
(2R,4S)-N-ALPHA-CARBOBENZOXY-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID
N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline
D-Proline, 4-hydroxy-, methyl ester, (4S)
N-Boc-4-oxo-L-proline methyl ester
2,5-Dibromo-N-[(3R,5S)-1-cyano-5-methyl-3-pyrrolidinyl]benzenesul fonamide
(2R,4S)-tert-Butyl 4-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Direct high-performance liquid chromatographic enantioseparation of secondary amino acids on Cinchona alkaloid-based chiral zwitterionic stationary phases. Unusual temperature behavior.

J. Chromatogr. A. 1363 , 169-77, (2014)

Two chiral stationary phases containing a quinine- or a quinidine-based zwitterionic ion-exchanger as chiral selector were applied for the enantioseparation of 27 unusual cyclic secondary α-amino acid...

Dye-linked D-amino acid dehydrogenase from the thermophilic bacterium Rhodothermus marinus JCM9785: characteristics and role in trans-4-hydroxy-L-proline catabolism.

Appl. Microbiol. Biotechnol. 99 , 4265-75, (2015)

A gene from the thermophilic Gram-negative bacterium Rhodothermus marinus JCM9785, encoding a dye-linked D-amino acid dehydrogenase homologue, was overexpressed in Escherichia coli, and its product wa...