Etiracetam

Suppliers

Names

[ Name ]:
Etiracetam

[Synonym ]:
1-Pyrrolidineacetamide, α-ethyl-2-oxo-
UCB 6474
(±)-a-Ethyl-2-oxo-1-pyrrolidineacetamide
ucb L059
T5NVTJ AY2&VZ
Etiracetam
2-(2-Oxo-1-pyrrolidinyl)butanamide
α-Ethyl-2-oxo-1-pyrrolidineacetamide
UNII:230447L0GL
Levetiracetam Racemic Mixture
乙拉西坦
2-(2-Oxopyrrolidin-1-yl)butyramide
(±)-α-Ethyl-2-oxo-1-pyrrolidineacetamide
2-(2-oxopyrrolidin-1-yl)butanamide

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
395.9±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₄N₂O₂

[ Molecular Weight ]:
170.209

[ Flash Point ]:
193.2±23.2 °C

[ Exact Mass ]:
170.105530

[ PSA ]:
64.39000

[ LogP ]:
-0.67

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.519

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS07, GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319-H411

[ Precautionary Statements ]:
P273-P305 + P351 + P338

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36

[ Safety Phrases ]:
S26

[ RIDADR ]:
UN 3077 9 / PGIII

Articles

Inhibition of excitatory synaptic transmission in hippocampal neurons by levetiracetam involves Zn²⁺-dependent GABA type A receptor-mediated presynaptic modulation.

J. Pharmacol. Exp. Ther. 348(2) , 246-59, (2014)

Levetiracetam (LEV) is an antiepileptic drug with a unique but as yet not fully resolved mechanism of action. Therefore, by use of a simplified rat-isolated nerve-bouton preparation, we have investiga...

Efficacy and safety of pregabalin versus levetiracetam as adjunctive therapy in patients with partial seizures: a randomized, double-blind, noninferiority trial.

Epilepsia 55(7) , 1048-57, (2014)

To assess the comparative efficacy and safety of pregabalin and levetiracetam for the reduction of seizure frequency in patients with partial seizures.This was a randomized, double-blind, flexible-dos...

The established status epilepticus trial 2013.

Epilepsia 54 Suppl 6 , 89-92, (2013)

Benzodiazepine-refractory status epilepticus (established status epilepticus, ESE) is a relatively common emergency condition with several widely used treatments. There are no controlled, randomized, ...