diethazine hydrochloride

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Names

[ CAS No. ]:
341-70-8

[ Name ]:
diethazine hydrochloride

[Synonym ]:
diethyl-(2-phenothiazin-10-yl-ethyl)-amine,monohydrochloride
Deparkin
diethyl-(2-phenothiazin-10-yl-ethyl)-amine,hydrochloride
Antipar
Diethazine hydrochloride
Diethazinhydrochlorid
Dinezin
Diparcol
Aparkazin
Thiantan
10-[2-(diethylamino)ethyl]phenothiazine hydrochloride
Thiontan
Dinezine
Latibon

Chemical & Physical Properties

[ Boiling Point ]:
422.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₃ClN₂S

[ Molecular Weight ]:
334.90700

[ Flash Point ]:
209.1ºC

[ Exact Mass ]:
334.12700

[ PSA ]:
31.78000

[ LogP ]:
5.49810

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO4375000

CHEMICAL NAME :: Phenothiazine, 10-(2-(diethylamino)ethyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 341-70-8

LAST UPDATED :: 199706

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C18-H22-N2-S .Cl-H

MOLECULAR WEIGHT :: 334.94

WISWESSER LINE NOTATION :: T C666 BN ISJ B2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - parasympatholytic

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 20 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

Safety Information

[ HS Code ]:
2934300000

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

Tyrocidine, hydrochloride
Triprolidine hydrochloride
Minoxidil hydrochloride
Elacridar hydrochloride
dodecylamine hydrochloride
Azetidine, hydrochloride, homopolymer (9CI)
1-(4,6-Dichloro-[1,3,5]-triazin-2-yl-amino)-imidazolidine-2,4-dione
Propyl 2-amino-5-methyl-4-(4-methylphenyl)-3-thiophenecarboxylate
Tert-butyl 2-(4-(6-methoxyquinolin-2-yl)phenylcarbonothioyl)hydrazinecarboxylate
3-Chloro-7-methoxy-4-methylisoquinoline
1,3-Dichloro-7-methoxy-4-methylisoquinoline
1,4-dimethyl-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole
Methyl 2-ethyl-2-(p-tolylsulfonyloxymethyl)-butanoate
2-Amino-N-cyclopentyl-4-(4-pyridinyl)-3-thiophenecarboxamide
(3-((3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl)methyl)piperidin-1-yl)(2-phenyl-2H-1,2,3-triazol-4-yl)methanone
(E)-1-(3-((3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl)methyl)piperidin-1-yl)-3-(furan-2-yl)prop-2-en-1-one

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